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Imaging Spatial and Social Brain Networks in Primates with a “CIM2” approach (Comparative, Immersive, Multimodal and Multicentric) – CIM2
Our scientific objective is to produce knowledge regarding three fundamental aspects of spatial and social cognitions: 1- What are the brain networks supporting spatial and social cognitions? 2- What are the relationships between the spatial and social brain networks? 3- What are the specificitie
How prefrontal dynamics emerge from cognitive training – PREDYCT
1. Reveal the neurophysiological basis of cognitive training and show how known frontal neural dynamics are established. a. Pilot neurophysiological recordings. b. Build free-access laboratory. c. Test training procedures and shape monkeys. d. Implant monkeys of Group 1 & train Group 1. e.
Brain mechanisms of dynamic behavioral adaptation – DYNADAPT
In everyday life, adaptation can be necessary for a number of reasons, making the study of the process challenging. Two classes of event can signal a need for adaptation: 1) Events caused by one’s own actions and specifically FeedBack –FB– from those actions (e.g. we adapt our strategy after an erro
Confidence, noradrenaline and adaptive learning – CONFI-LEARN
We previously developed a learning task which is simple enough to be carried in the laboratory to study adaptive learning. In this task, we present sequences of observations to participants and ask them to predict the upcoming observation. The true underlying probabilities actually change without wa
The Costs of Cognition from an Information-Theoretic perspective: experimental validation – CoCogIT
The first objective of the present project is to provide empirical evidence for the link between information cost and cognitive effort and to assess the validity of the local and global limited capacity hypotheses regarding the nature of this link. This issue will be tackled in work package 1 (WP1).
Cognition and brAin Development in AdolEscents with Tourette Syndrome – CADETS
The aims of the present project are threefold: Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents. To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) rewa
Cerebellar molecular layer interneuron network activity and function during walking and obstacle crossing – WalkingCrossingNeurons
We aim to characterize the activity patterns of the molecular layer interneuron (MLI) network and examine its role for Purkinje cell (PC) firing in awake mice walking on a runged treadmill and crossing obstacles. We will furthermore construct a spiking neuron network model of the MLI network and use
Alterations of cerebral functional connectivity associated with persistent pain – PINCH
In the field of neuroimaging, studies of functional connectivity (FC) have revealed important new insights in various neurological and psychiatric disorders. FC is a set of temporally correlated haemodynamic fluctuations that defines a neuronal network. In the brain of chronic pain patients, study
Reaching a cell-type specific level of understanding in depression – DEPth
The main goal of this project of translational research is to reach cell-type specific understanding of depression, investigating the electrophysiological and molecular alterations in the glutamate (GLU) and gabaergic (GABA) neurons of the anterior cingulate cortex (ACC) in depression. Based on the
miRNAs and networks of co-expressed genes associated with childhood trauma: from molecular scars to drug discovery in bipolar disorders – CT-ScarBip
The first clinical objective of this project is a validation of CT as a disease modifier (prediction of mood recurrences) in a prospective sample of patients with BD, most previous studies using a retrospective design. The second molecular objective is to generate an integrated mRNA and miRNA blood
Mapping and predicting trajctories for eye movements – PREDICTEYE
Events from the external world most often have statistical regularities that we can capture and use to predire future events and plan for motor responses. For instance, catching a prey is eagerly easy for rectilinear trajectories but far more complex with naturalistic, prey-like trajectorties. Our p
Do human and artificial intelligence share semantic representations? – AI-REPS
Recent developments in AI (artificial intelligence) and deep learning are revolutionizing technology and society. Cognitive neuroscience can draw inspiration from these deep neural networks (DNNs) to understand important brain functions like face recognition in vision, or word and sentence comprehen
Movement disorders in Parkinson’s disease: The role of somatosensory deficits and cerebellar anomalies – SENCE
Deficits in motor functions in Parkinson’s disease (PD) have usually been attributed to dysfunctional output of the basal ganglia (BG) to the motor system. However, the nature of the motor impairments caused by dopamine depletion is still debated. Moreover, efficient control of movement relies on op
Elucidation of a brain network underlying social memory – WhoRU
While the ability to form and recall memories is essential for survival, it is also key to forming relationships with others and defines our sense of self. The hippocampus has long been recognized as a fundamental structure for learning and memory formation. Many lesion studies of human patients ove
Disrupting dopamine-glutamate receptor complexes to alleviate stress-related mental disorders – DropStress
Stress is a key factor that predisposes to many mental disorders, such as major depression, anxiety or substance use disorders (SUD), and hinders remission. There is a strong co-morbidity between SUD and people diagnosed for mental disorders, notably anxiety and depression. Current therapies primari
Prefrontal long-range inhibitory control of fear behavior – PRELONGIN
This project addresses the question of how specific long-range cortical inhibitory projections can control fear behavior. Although cortical inhibitory projections have been described in the past, the functional role of such inhibitory projection in the context of fear behavior is largely unknown. To
Taste Perception and Modulation in a Miniature Brain – APITASTE
Taste allows distinguishing between chemical compounds and the sensations they produce based on contact with chemoreceptors. It allows animals and humans to discriminate edible from non-edible items and is, therefore, crucial for survival. The question of how taste information is encoded and modulat
A new non-human primate model for translational brain research – Marmobrain
Thanks to their homology with humans at multiple levels, non-human primates are key animal models for investigating the neural underpinnings of brain functions in normal or pathological conditions. Over the last 5 years, the marmoset monkey model has quickly established itself as a worldwide new st
Multiscale study of social learning and memory in Drosophila melanogaster: from genes to animal culture – MoleCulture
Neuroscientists are unanimous in recognizing that experiences influence brain, which in turn influences experiences. For instance, individuals can learn from their own experience. However, individuals can also learn from the observation of the experience of other individuals, a process called “obser
Exact Reduction of Multiscale Neural Dynamics – ERMUNDY
The dynamics of large-scale brain networks are at the origin of the signals measured via human invasive and non-invasive recordings and imaging. The recent decade saw the emergence of a novel generation of mathematical network models acknowledging the large-scales, using personalized connectivity ma
Multiscale dynamics of learning in auditory cortex – DynaMiC
Learning is a fundamental property of the cortex, enabling a broad range of cognitive functions occurring on multiple spatial and time-scales. However, the temporal dynamics and spatial interactions of the neural mechanisms underlying auditory learning remain largely obscure because of the large cha
Decomposing the retinal circuit – DECORE
A major challenge in sensory neuroscience is to understand how neural circuits process complex, natural stimuli. Even at the level of the retina, this understanding is limited. Several circuits often shape the response of sensory neurons to the stimulus, and separating their respective roles is ch