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It is now well demonstrated that cancer that’s diagnosed at an early stage is more likely to be treated successfully. This is particular true for pancreatic ductal adenocarcinoma (PDAC) that remains asymptomatic. Consequently, there is an urgent need to identify biomarkers useable in the diagnosis.

BK virus (BKV) infection has a major negative impact on the transplant recipient community. It is estimated that up to 30% of the 60,000 kidney transplants performed annually worldwide are potentially compromised by BKV-associated nephropathy (BKVAN) or BKV replication. Furthermore, prolonged BKV re

Mesial temporal lobe epilepsy (TLE), one of the most common forms of epilepsy in adults, is frequently intractable. We have recently explored the pathophysiological implications of kainate receptors (KARs) in chronic seizures in a mouse model of TLE. We have demonstrated that aberrantly expressed sy

The control and the regulation of the mitochondrial Ca2+ homeostasis is a primary sensor of the cardiac metabolic disorder. We here propose that (i) MCU expression, structure and function integrates cardiac metabolic flexibility, (ii) the MCU composition dynamically affect mitochondrial Ca2+ homeost

During last decade, scientific community has shown strong interest for hybrid nanoparticles and their biomedical applications as highlighted by the growing number publications on this field of research. Despite this academic research, only a small number of nanoparticles succeeds to go in clinic. It

Structural and functional abnormalities of the cutaneous microcirculation in diabetic patients with ulcer support its critical role in the pathophysiology of DFUs. However, the detailed mechanisms underlying such dysfunction remain largely unexplored. The prostacyclin (PGI2) is an important regulato

During the past years, our group have shown that accurate examination of medical imaging and electrophysiology can help better individualize subgroups of patients and define specific therapeutic approaches. In addition, we recently identified autoantibody targets in patients with chronic inflammator

Several pathological situations result from the inability of the organism to mount immune tolerance towards exogenously administered molecules, as observed in alloimmune responses to protein therapeutics. This is particularly true of hemophilia A, a rare X-linked recessive life-threatening, cripplin

The main objective of the EpiReg project is the identification of genetic drivers for epilepsy by integrating systems genetics approaches and experimental functional in vivo expertise of the INSERM U1141 collaborators. The epilepsy-associated gene regulatory network M30 was previously identified (re

Several arboviruses, such as dengue fever, Zika fever, chikungunya, or West Nile virus circulate simultaneously in the same geographical areas. It would be interesting to have multivalent vaccines against several of these infections which can be fatal. This new vector has been constructed. It makes

Rhabdomyolysis (RM) results from a impairment in ATP metabolism and a deregulation of ion channels, leading to a rapid increase of cytoplasmic ionized calcium concentration and the destruction of muscle cells. Although rare, the prognosis of RM related to Inherited Metabolic Diseases (IMD) is poor,

To date, the repair of critical sized bone defects remains a clinical unmet need. Autograft, the current gold standard, presents several drawbacks justifying safer strategies. “Orthobiologics” products that combine synthetic grafts, mostly collagen sponges and ceramics, and bioactive molecules such

In the last decades, advances in Intensive Care Unit management have led to decreased mortality. However, significant morbidity remains as patients survive after a lesional coma with uncertain quality of awakening and high risk of functional disability. The possible dissociated consciousness recover

Alcohol consumption during pregnancy constitutes the main cause of acquired handicap and most children presenting fetal alcohol spectrum disorders (FASD) are not diagnosed at birth. However, these infants are not devoid of neurodevelopmental troubles that will be detected at school-age. Neonatal dia

Narcolepsy type 1 (NT1) is a disabling orphan disorder characterized by excessive daytime sleepiness and cataplexy, often associated with hypnagogic hallucinations, sleep paralysis, nighttime sleep disruption and weight gain. NT1 is a chronic disorder, and in the large majority of patients it is a s

Multiple sclerosis is the prototype autoimmune disorder of the central nervous system. Effective therapies to reverse neuronal damage and restore function are a major unmet need. New drugs that promote the formation of myelin may be effective in reducing long-term disability. An associated imaging m

Acquired chronic isolated thrombocytopenias are frequent disorders. Most of them are related to an auto-antibody mediated destruction leading to the diagnosis of Immune Thrombocytopenic Purpura (ITP). We previously demonstrated that some of these ITP are not due to an immune disorder, but rather are

Onchocerciasis is a parasitic vector-borne disease caused by the filaria Onchocerca volvulus (Ov) prevalent mainly in Africa. Due to its ocular and cutaneous complications, individual and public health burden are high where infection prevalence exceeds 40%. Since 1989, populations in such “meso-hype

Systemic lupus is a rare autoimmune disease leading to end stage renal disease (ESRD) in 25% of cases. It highlights the need for treatment innovation for systemic lupus and lupus nephritis. Despite important efforts made by the medical community, research groups, and pharmaceutical companies, rando

Centronuclear myopathies (CNM) are rare congenital myopathies characterized by abnormal centralization of nuclei in muscle fibers. Three main forms of CNM are distinguished: The X-linked recessive CNM (also called X-linked myotubular myopathy, XLMTM) due to mutations in myotubularin (MTM1), the auto

Background: In 2017, World Health Organization reinstated snakebite envenoming to its priority list of neglected tropical diseases. In France, concern is related to the fashion of maintaining exotic snakes as pets, whereas Bothrops sp. are responsible for life-threatening envenomations in French guy

Non-alcoholic fatty liver disease (NAFLD) encompasses a wide range of pathologies from steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and finally cirrhosis. It is a very common pathology during type 2 diabetes (T2D), resulting in excess mortality. NAFLD also promotes the development of

Chronic diseases are the main cause of death with a major burden on health budgets and economic losses. In TYPE 1 DIABETES MELLITUS destruction of pancreatic beta-cells leads to absolute insulin deficiency and concerns 5-10% of the current 371 million diabetes patients, expected to rise to 592 milli

Autoimmune diseases are considered to be multifactorial diseases with complex genetic backgrounds. Nevertheless, we have discovered monogenic cause of early-onset autoimmunity. The present project focuses on the genetic and pathophysiological studies of the pediatric Evans Syndrome (pES), a rare aut

Acute HF represents a huge financial burden on global healthcare systems due to the resources and costs associated with the hospitalization of a patient. Moreover, post-discharge readmission rates are extremely high in acute HF patients. Despite the number of people affected worldwide by acute HF, n

Mycobacterium tuberculosis (Mtb) is responsible of clinical conditions going from latent tuberculosis (TB) infection (LTBI) to active TB. Real-time biomarkers for diagnosis of both active TB and LTBI, and for therapeutic efficacy are mostly needed. Among host immune effectors preventing active TB de

Chronic lung allograft dysfunction (CLAD) is the main limitation of long-term survival after lung transplantation. Although several risk factors of CLAD have been identified, pathophysiological pathways and molecular triggers remain unknown. Moreover, no integration of risk factors is performed in c

Half of the world population is exposed to risk of malaria infection. Artemisinin derivatives are the most efficient and recommended treatment for malaria. Through their mode of action artemisinin derivatives induce pitting (expulsion of death parasite by the spleen without lysis of the host red blo