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Superconducting motor for aircraft application – FROST
Air transport has grown by about 9% every year since 1950 and has made the world smaller on a human scale. However, commercial flights remain expensive and account for 2% of human emissions of CO2. As a result, airlines and the aviation industry envision tomorrow's transportation, which will require
Sublingual Vaccination by polysaccharide-based patch – BuccaVac
We propose a pioneering approach that has never been addressed to date and will go well beyond the current state-of-the-art strategies for sublingual vaccination: association of a mucoadhesive delivery system with a particulate antigen formulation containing an immunostimulant. Such new technology i
Sub-Riemannian Geometry and Interactions – SRGI
cf pdf cf pdf cf pdf cf pdf Sub-Riemannian manifolds provide an important mathematical model for many problems involving some nonholonomic constraints. Since several years, there has been an impressive revival of interest in sub-Riemannian geometry (in short, SR geometry), together with many emergin
Sub-Exponential Approximate and Parameterized Algorithms – S-EX-AP-PE-AL
The topic of this project is the design of efficient approximation algorithms for NP-hard combinatorial optimization problems. Such problems abound in all fields of science and engineering - in fact the vast majority of interesting problems are NP-hard and therefore do not admit fast (polynomial-tim
Structure-function relationships of Ferric Uptake Regulators and their inhibitors: towards new peptido-siderophore antibacterial compounds – PepSiFUR
Iron homeostasis and virulence of pathogens are intimately linked. A key actor of this metabolism in bacteria is the Fur protein (Ferric uptake regulator), a global transcriptional regulator of the expression of the genes involved in iron homeostasis. Any perturbation of Fur activity will affect pro
Structure and function of the cellular target of the anti-Shiga toxin drug candidate Retro-2.1 – SMERSEC
The new chemical entity Retro-2 has a remarkable capacity to protect cells and mice from Shiga-like toxins, ricin, and a number of viruses, without toxicity. The optimized analogue Retro-2.1 is being developed as a drug candidate to prevent the hemolytic and uremic syndrome, a deadly complication of
Structural optimization and preclinical validation of ABCB4 correctors – SOPREVAC
Bile secretion facilitates the digestion of dietary fats and the elimination of endogenous and exogenous toxic substances. This vital function is carried out by the liver and begins at the canalicular membrane of hepatocytes, wherein transmembrane proteins such as the ABCB4 transporter secrete phosp
Structural geometric approximation for algorithms – SAGA
Combinatorial optimization arises naturally in a variety of resource management problems in public transportation companies, industrial manufacturing, financial and health-care institutions. Standing out are two categories of optimization problems, packing and covering, with applications in material
StrUctured Graphene frameworks designed for Electrochemical Storage – SUGGEST
The aim of this project is to develop chemically designed 3D graphene architectures with the objectives to favor the intercalation of both cations such as Li+, Na+, but also Ca2+, Mg2+ and Al3+, and/or anions (PF6-, BF4-, TFSI) in batteries or dual cells by controlling the interlayer distance betwe
Stoichiometry, Structure and Strain Engineering in LiNbO3 and LiTaO3 thin films deposited by PI MOCVD – LiLa
Although LiNbO3 and LiTaO3 films have been fabricated by different techniques, many electrical and electro-optical properties reported are not comparable for those of LiNbO3 and LiTaO3 single-crystals. Thus, the degradation of physical properties in thin films can be explained by the difficulty to c
