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Statistics and Machine Learning for Single Cell Genomics – SingleStatOmics
The ability to measure genome-wide gene expression or mutations from large cell populations revolutionized biology in the late 1990s, enabling characterization of cancer subtypes and comprehensive gene expression profiling. However, traditional bulk genomics masks critical cell-to-cell variability w
A CONVENIENT APPROACH TO GLYCOAMPHIPHILES AS ACTIVE LAYERS OF LCD-BASED BIOSENSORS – SWEET-DISPLAY
In our bodies, as in plants and bacteria, certain molecules called glycoconjugates play an essential role. These molecules are formed of sugars attached to proteins or fats, and are found in particular on the surface of cells. They enable communication between cells, recognition of microbes, and par
Gouvernance des systèmes urbains pour une ville résiliente – RESILIS
Cities are becoming more and more complex with social interactions, high degree of connectivity and competitiveness objectives. If urbanity results from resources accumulation, power concentration, territory attractiveness and culture, it is also a risk producer. Risk management is mainly focused on
Investigating large scale bioreactor effects in microbial application – ScaleApp
Traditional bioprocessing engineering-based scale up procedures cover reactor design and stirrer operation, but not physiological adaptation of the cells to variable environmental conditions prevalent in such technical cultivation systems. This decoupled approach between engineering and microbial ph
Aerosol-Cloud Interactions: the role of organic compounds on cloud droplet activation – ORACLE
Cloud droplets in the Earth’s atmosphere form on ubiquitous aerosol particles. Predictions of cloud droplet size and number concentration derived from aerosol properties are still poor, leading to large uncertainties in the radiation budget and climate projections. Cloud droplet formation on cloud c
Surface structuration for high mobility Silicon Carbide MOSFETs – riseMOS
Sustainable energy production and efficient energy conversion are major concerns of our society. Silicon carbide (SiC) metal-oxide semiconductor transistors (MOSFETs) have thus taken on strategic importance in decentralized electrical distribution grids or electrical system controls. They increase s
Single-cell imaging of host-parasite metabolic interactions in the liver – iMET
The main focus of the project is the AMP-activated protein kinase (AMPK), the master regulator of global cellular metabolism. Because of emerging single-cell scale technologies revealing a significant spatial heterogeneity in hepatic AMPK gene expression and function, and because Plasmodium hepatic
3D Bragg ptychography: Developments for metallic nano-twinned thin films – PtyMet
The project is built on two objectives: the first concerns materials, the second is more methodological. Indeed, we want to develop nano-twinned gold thin films. We believe that these films will combine ductility (because gold is initially ductile and that the twins can migrate or enlarge), mechanic
Sublingual Vaccination by polysaccharide-based patch – BuccaVac
We propose a pioneering approach that has never been addressed to date and will go well beyond the current state-of-the-art strategies for sublingual vaccination: association of a mucoadhesive delivery system with a particulate antigen formulation containing an immunostimulant. Such new technology i
Gas-liquid plasma micro-reactors for future chemistry – PLAS4CHEM
The long term objective of the project is to develop a new tool able to perform chemical reactions of industrial interest without catalysts and without solvents, using reactive species (radicals, excited neutrals, metastables, photons…) generated in gas phase by plasma discharges at room temperature
