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Treatment of proton transport-related congenital disorders of glycosylation by manganese supplementation – TreatProCDG
Glycosylation is a protein and lipid posttranslational modification influencing many biological and physiological processes. Thousands of proteins are ‘glyco-proteins’. As a result, genetic defects in glycosylation pathways lead to mostly severe diseases, called ‘Congenital Disorders of Glycosylatio
Tricyclic-Spirolactams for the treatment of non-tuberculous mycobacteria Infections – TriSLa-4-NTM
Infections caused by Non-Tuberculous Mycobacteria (NTM) are on the rise worldwide, not only in cystic fibrosis and immuno-compromised patients, but also in immune-competent individuals. These infections represent a major healthcare challenge with treatment using current antibiotics remaining less th
Tridimensional micro-conveyance systems for micro-factory – ALVEO
The work proposed in the ALVEO project takes place in the context of the microfactory, a means of production particularly well suited to the manufacture of miniature objects (microelectronics, micromechanics, watchmaking, etc.) in small and medium production runs. Microfactories require a high level
Triggering selective apoptosis of multidrug resistant cancer cells overexpressing ABC transporters – Achilles
The aim is to identify compounds targeting multidrug-resistant cancer cells overexpressing ABC transporters for triggering their apoptosis. These compounds, by difference to classical inhibitors of drug-efflux pumps, produce collateral effects by targeting critical components of the pathophysiologic
Tropospheric Ozone in Southeast Asia: Budget and Mitigation Strategies – OSEAMS
On regional and global scales, tropospheric ozone is a key compound controlling atmospheric oxidation capacity and an important driver of climate change. On a local scale, ozone is a criteria air pollutant that has detrimental effects on human health and natural ecosystems. Although having successfu
Two-Dimensional Nanomaterial-based Metasurfaces for enhanced Plasmonic Sensing – 2DPS
Surface plasmon resonance (SPR) sensors are optical sensors commonly used for real-time monitoring of molecular interactions. Graphene is the thinnest 2D material and its high charge carrier mobility makes it an attractive material for these sensors. By applying graphene layers on the top metal laye
Two-component Functional organOGELs – FOGEL
As stated in the National Strategy for Research report (SNR, Action Plan 2016 , ANR Call), while presenting one of the five priorities of Challenge 3 "Industrial Renewal" (Priority 14 "Design of new materials"): " The products of the future will be more complex and mix several materials endowing fin
Ultra Low Power Wake-up Radio – U-WAKE
Several use-cases of a wake-up radio can be identified (ultra-low power but small sensitivity or more consumption but better sensitivity). From a general point of view, the interesting parameters are: • Consumption - in nW • Sensitivity (S/N detection threshold) • Frequency band and carrier frequ
Ultrafast energy transfer in single nano-objects – ULTRASINGLE
The modalities of energy transfer at the nanoscale differ markedly from those at the macroscopic scale, in particular because of the increased role played by the interfaces. The partial reflection of phonons at interfaces induces in particular thermal resistances which play a central role at the nan
Ultrafine-grained materials processed by fast Dynamic Plastic Deformation – MAUDE
One of the objectives in the design and materials engineering has always been to facilitate their use directly or improve their properties to continue to push the boundaries of human activity. Nowadays, materials with higher performance are required, which, inevitably is accompanied by pressure on t
