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Manipulation of intracellular microbial sensors by the stealth pathogen Coxiella burnetii – ST-Health
Along evolution, intracellular bacterial pathogens have developed elaborated means to counter the immune response of their host in order to establish optimal replicative niches in which they replicate in high numbers. This is achieved by the secretion of bacterial effector proteins that divert the f
Adjusting nitrate fluxes in plant growth responses to shade or temperature – NitReST
Plants constantly adjust their development in response to variations of environmental parameters, both above and below ground. How do plants sense and integrate various concomitant external signals? How does each signal influence the response to another? These questions are at the heart of the NitRe
Reliability and high torque and power density motor – REdHat_Motor
The electric driving chain constitutes a solution for mobility issues. For economic, ecologic and energy reasons, their power and their torque, with respect to their mass and volume, must be improved, and especially the electrical machines equipping the vehicles. The main goal of the project is to i
Lab-on-a-chip model of mucociliary clearance for the treatment of Inflammatory Lung Diseases – MucOnChip
The Global Burden of Disease Study reports around 4 million deaths each year worldwide for inflammatory lung diseases, the large proportion of which occurring in low- and middle-income countries. Inflammatory lung diseases include asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibro
Natural Working Fluids for Absorption Refrigeration – AWARE
European and global regulations on greenhouse gases are constantly evolving. Most of the fluorinated refrigerants currently used are close to be banned due to their high global warming potentials.The most widely used refrigeration system is the vapor-compression refrigeration cycle including an elec
Quasi Cyclic Small Packet – QCSP
The publication of 3GPP Release 15 in June 2018 paved the way for the new 5G air interface, making a new step towards the new generation of mobile networks. The work on the development of a new radio interface dedicated to Internet of Things (IoT) connectivity should then start in 2020. It is expect
Monitoring by EEG for the evAluation of Somnolence to improve SAFEty – MEEGASAFE
Drowsiness is an intermediate state between wake and sleep that induces an instable wake state and impairs motor and cognitive performances. Drowsiness has been identified as a major cause of traffic, professional and domestic accidents, associated with human, economic and social consequences. Even
Cleaving membrane necks by ESCRT-III – Neck4Fission
The "endosomal sorting complex required for transport" (ESCRT) catalyzes a wide range of physiological and pathological membrane remodeling processes including budding of vesicles and enveloped viruses, cell division and many others involving topologically similar inside-out budding processes. The e
Chloride Deregulation in Epileptic Focal Cortical Dysplasia – DYSCLO
Focal cortical dysplasia (FCD) are epileptogenic malformations of cortical development leading to drug resistant epilepsy in children. Surgical treatment is the gold standard to treat these patients and offers the unprecedented opportunity to better understand the mechanisms of epilepsy exvivo. I ha
Synthetic metabolic and genetic networks for medical diagnostics – SynBioDiag
Organisms have evolved to sense large panels of metabolites and human have used these sensing abilities throughout history. Recently, synthetic biology has expanded and rationalized biosensing by engineering whole-cell biosensors (WCBs) with sophisticated signal processing capabilities. The main adv
