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New catalysts for SAFe HYdrogen Release and use – SAFHYR
The two couples perhydrodibenzyltoluene/dibenzyltoluene and acetone/isopropanol involved in transfer hydrogenation operate in a closed circuit, with only hydrogen being able to enter and leave the circuit. This process, which is athermal and safe (no molecular hydrogen is released), could be a signi
Lab-on-a-chip model of mucociliary clearance for the treatment of Inflammatory Lung Diseases – MucOnChip
The Global Burden of Disease Study reports around 4 million deaths each year worldwide for inflammatory lung diseases, the large proportion of which occurring in low- and middle-income countries. Inflammatory lung diseases include asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibro
Deep Learning meets Numerical Analysis – DeepNuM
OBJECTIVE: DeepNuM aims at developing the interplay between two families of computational approaches, Deep Neural Networks (DNNs) and Partial Differential Equations (PDEs), with the goal of modeling complex dynamical systems arising from the observation of natural phenomena. Three central questions
An innovative non-mutant neoepitopes-based immunotherapy targeting immune-escaped tumors – NEOCOMBO
Although promising, immunotherapies targeting PD-1 are effective in only a fraction of cancer patients and the mechanisms associated with resistance are poorly elucidated. Indeed, tumors use additional pathways to evade CD8 T-cell recognition in particular alterations in peptide transporters TAP. We
Gene therapies approaches for Charcot-Marie-Tooth diseases: targeting the right cell type and compartment – GENERATE
Charcot-Marie-Tooth disease (CMT) is a hereditary disorder that affects the nerves outside the brain and spinal cord. It affects about 300,000 people in Europe. The disease progresses slowly and causes muscle weakness, especially in the legs, as well as sensory problems, often detected in childhood
Cationic Covalent Organic Frameworks as Anion Exchange Membranes for Electrochemical Energy Applications – COFFEE
The COFFEE project is a fundamental research project that seeks to combine research expertise from different European research institutes and universities, across multiple areas of materials chemistry to develop innovative anion exchange membrane (AEM) solutions for electrochemical energy conversion
How does Chaos drive Transport Dynamics in Porous Media ? – CHORUS
Fluid flow in porous media plays a central role in a large spectrum of geological, biological and industrial systems. Recent advances have shown that microscale chemical gradients are sustained by pore-scale chaotic flow dynamics. This fundamentally challenges the current macrodispersion paradigm th
High-dimensional mathematical methods for LargE Agent and Particle systems – HighLEAP
Interacting particle- or agent-based systems are ubiquitous in science. They arise in an extremely wide variety of applications including materials science, biology, economics and social sciences. Several mathematical models exist to account for the evolution of such systems at different scales: sto
Colloidal control of multi-phase flow in geological porous media – COCONUT
The COCONUT project aims at developing predictive capabilities to understand how colloids (nanometals, fine particles, bacteria, viruses, asphaltenes..) control immiscible two-phase flow in complex geological formations. Colloids (including nanoparticles) have an incredible potential to remobilize n
Photosynthetic energy networks for the functioning and regulation of the algal CCM – AlgalCCM
Microalgae account for nearly half of the CO2 annually fixed by the Earth’s ecosystems. Because CO2 diffusion is slow in water and the CO2-fixing enzyme of photosynthesis (Rubisco) has a low affinity for CO2, the efficiency of microalgal photosynthesis greatly depends on a mechanism that concentrate
