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Tricyclic-Spirolactams for the treatment of non-tuberculous mycobacteria Infections – TriSLa-4-NTM
Infections caused by Non-Tuberculous Mycobacteria (NTM) are on the rise worldwide, not only in cystic fibrosis and immuno-compromised patients, but also in immune-competent individuals. These infections represent a major healthcare challenge with treatment using current antibiotics remaining less th
Treatment of proton transport-related congenital disorders of glycosylation by manganese supplementation – TreatProCDG
Glycosylation is a protein and lipid posttranslational modification influencing many biological and physiological processes. Thousands of proteins are ‘glyco-proteins’. As a result, genetic defects in glycosylation pathways lead to mostly severe diseases, called ‘Congenital Disorders of Glycosylatio
Trapped circular Rydberg atoms for Quantum Simulation – TRYAQS
TRYAQS proposes a disruptive concept for the quantum simulation of complex systems. Many groups worldwide actively explore quantum simulation. It aims at an in-depth understanding of many-body systems. They are extremely important, both for fundamental issues such as quantum transport or quantum pha
Transport and Adsorption in MultiScale Porous Materials – TAMTAM
Hierarchical porous materials, combining multiple porosities, are widely used in industry (adsorption, separation, catalysis) to overcome slow diffusion in microporous solids ( < 2 nm) and increase access to their large surface area. The benefits of combining porosities by adding meso (2-50 nm) and
Tractable quasI-Newton non-smooth Optimization Methods for large scale Data Science – TRINOM-DS
Structured composite non-smooth optimization has proved to be extremely useful in data science, where a common trend is the deluge of large-scale multidimensional data, which drives the need for more efficient optimization schemes. While, so far, primarily, first-order schemes have been widely used
Towards orbitronics function in transition-metal-oxide heterostructures: a novel paradigm in oxide electronics – ORBIFUN
This project aims at unlocking the potentialities of the orbital-physics of Transition Metal Oxides (TMOs), establishing the basis for novel orbitronics function. The principal aspiration of this promising area of research is to switch between two electron orbital states via an external stimulus, su
Towards clinical investigation on the use of Mineralocorticoid Receptor Antagonist for wet Age-Related Macular Degeneration – MR-A-MD
Strategies that aim at extending the duration of anti-VEGF effects (gene therapy, small antibodies, implantable reservoir) will not benefit to all patients because VEGF is not the only molecular target in AMD31. MR-A-AMD aims at validating that MR pathway is a novel and pertinent target to be tested
Towards a smart blood culture bottle: Machine learning assisted electrochemical profiling to provide early in-situ identification of bloodstream infection pathogens – E-MOC
Despite all improvements in the diagnosis of infectious diseases in the last 20 years, the socioeconomic burden of bloodstream infections (BSI) is still high for every country all around the world. Approximately 20% of global mortality worldwide (11 million deaths per year) is related to sepsis. Thu
Towards a complete CO2 hydrate slurry-based cooling application – COOLHYD
With a cost equivalent to 20% of global electricity consumption, and highly regulated refrigerants, the refrigeration industry must face several challenges of sustainable development while ensuring its fundamental role for various sectors (food, air conditioning…). The use of phase change material (
Towards a Better INtegration of the Aggressiveness of Road loads experienced bY wearing course – BINARY
The aim of the project is to develop more rational and scientific approaches for assessing the effect of traffic loads on wearing courses and for the design of these layers. To achieve these goals, the main mechanisms of deterioration of wearing courses under traffic loads, such as raveling, strippi
