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Roscovitine analogues as targeted pharmacotherapies for rare cholestatic liver diseases – RAPRACLID
Bile secretion is an essential function of the liver necessary for fat digestion as well as elimination of xenobiotics and endogenous metabolites. This function mainly depends on ATP-Binding Cassette (ABC) transporters located at the canalicular membrane of hepatocytes and responsible for the secret
Dynamics and nanoscale topology of the membrane-associated Rab11-vRNP complex in the context of influenza virus-infected cells – FluNanoTrack
Influenza A viruses (IAV) pose a serious threat to global public health. Development of improved influenza prevention and therapy, whether it be the universal vaccine or novel anti-influenza drugs, will depend strongly on fundamental science improving our understanding of the molecular mechanisms in
Matrices spectral structures in graph learning and its applications – MASSILIA
This project aims at tackling current problems related to graph learning and its applications in a unified way centered on the spectral decomposition of the graph Laplacian (and/or adjacency) matrix. The objectives are the following 1) directly control the graph spectral parameters within a robust l
Manipulation of intracellular microbial sensors by the stealth pathogen Coxiella burnetii – ST-Health
Along evolution, intracellular bacterial pathogens have developed elaborated means to counter the immune response of their host in order to establish optimal replicative niches in which they replicate in high numbers. This is achieved by the secretion of bacterial effector proteins that divert the f
Porous hydrogel under perfusion: modeling and optimization of an in vitro model of bone defect reconstruction – HydrOs
Bone is a living tissue that is subjected to various stimuli. Cells receive mechanical, chemical or biophysical signals through their environment. The information translates into a capacity to adapt to any environmental modification. In the context of bone tissue engineering (BTE), this property can
Adjusting nitrate fluxes in plant growth responses to shade or temperature – NitReST
Plants constantly adjust their development in response to variations of environmental parameters, both above and below ground. How do plants sense and integrate various concomitant external signals? How does each signal influence the response to another? These questions are at the heart of the NitRe
Search for new THERMOelectric and magnetic chalcogenides with DFT as a guiding tool – ThermoDFT
The search for thermoelectric materials is an active topic, and promising new families such as chalcogenides have emerged in recent years with the figure of merit ZT reaching 1 or above. One of the possible tuning parameters of ZT in chalcogenides containing transition-metal cations is magnetism whi
Natural Geotextiles in green road infrastructures – GEONAT
Petrosourced geotextiles have been widely used for several decades in road structures, in particular for separation function. They preserve the characteristics of the subgrade by limiting contamination by fine materials from the fill layer. They are of economic and ecological interest, both because
Artificial Intelligence Methods for Energetic Particle transport in fusion plasmas – AIM4EP
Energetic particles are ubiquitous in magnetically confined fusion plasmas. They contain a significant fraction of the plasma energy and are thus vital for the performance of fusion devices such as ITER. However, the presence of energetic particles and the fact that fusion plasmas are complex system
Operando investigation of chemo-mechanical degradation in sulfide-based solid electrolyte – OpInSolid
All solid-state batteries based on thiosulfate solid electrolyte hold the promise of safer and more energetic batteries, especially once coupled to Li metal anode and high voltage cathodes. Unfortunately, it was demonstrated in the literature that their electrochemical stability window is far from o
