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Towards clinical investigation on the use of Mineralocorticoid Receptor Antagonist for wet Age-Related Macular Degeneration – MR-A-MD
Strategies that aim at extending the duration of anti-VEGF effects (gene therapy, small antibodies, implantable reservoir) will not benefit to all patients because VEGF is not the only molecular target in AMD31. MR-A-AMD aims at validating that MR pathway is a novel and pertinent target to be tested
Evaluating and managing the migration of contaminants from cellulosic materials – FoodSafeBioPack
The FOODSAFEBIOPACK project offers THREE significant contributions. (1) The transfer conditions will be exhaustively qualified by food type and modality for packaged foods sampled from the market by using a new design of migration cells enabling humidity control, freezing, and oven heating. (2) The
Heat Management in the Ballistic Limit at the nanoscale – HANIBAL
The manipulation of heat fluxes is possible by acting on the transport of phonons at the nanoscale in thermal metamaterials. This is one of the major challenges of the current small-scale energy management. In order to demonstrate innovative effects involving large phonon mean-free-paths and long ph
Yarrowia lipolytica oleochemicals based on odd chain fatty acids – YaLiOl
The objectives of the YaLiOl project are to: 1) to advance the engineering of Y. lipolytica for the production of odd-chain fatty acids (OCFA); 2) to develop a fermentation medium based on sugar beet molasses; 3) recovering the OCFAs, characterizing them, and transforming them into oleochemical
The return to an aquatic life, the evolution of propulsive efficiency & biomimetics – DRAGON2
The return to an aquatic life has shaped many organisms and profoundly impacted fossil and extant marine ecosystems. Understanding how terrestrial organisms adapted to a drastically novel environment poses fundamental challenges, however. Indeed, in most lineages this major transition entailed deep
AUTOmated exploration of MATerials for PROton-conducting solid oxide CELLS – AUTOMAT-PROCELLS
Solid Oxide Fuel/Electrolysis Cells are electrochemical devices based on ceramics which operate at high temperature, typically 600-800 °C. This high temperature is needed to ensure fast diffusion and reaction rates i.e. to allow for high power efficiency. Unfortunately, coupled with extreme operatin
Schrödinger problem, optimal transport and stochastic calculus – SPOT
The goal of this project is to study the most probable trajectory followed by an interacting particle system when a spontaneous fluctuation is observed. In its most basic form, this is known as the Schrödinger problem. In their general form, the problems at the heart of this project are formulated
Free space Isomorphisms and Isometries – FRII
This project aims at substantially advancing the knowledge about Lipschitz-free spaces and their applications to metric geometry and to functional analysis. For a metric space (M,d) the free space F(M) is a Banach space that is built around the metric space M in such a way that M is isometr
Single-cell imaging of host-parasite metabolic interactions in the liver – iMET
The main focus of the project is the AMP-activated protein kinase (AMPK), the master regulator of global cellular metabolism. Because of emerging single-cell scale technologies revealing a significant spatial heterogeneity in hepatic AMPK gene expression and function, and because Plasmodium hepatic
Chloride Deregulation in Epileptic Focal Cortical Dysplasia – DYSCLO
Focal cortical dysplasia (FCD) are epileptogenic malformations of cortical development leading to drug resistant epilepsy in children. Surgical treatment is the gold standard to treat these patients and offers the unprecedented opportunity to better understand the mechanisms of epilepsy exvivo. I ha
