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Metabolic interactions between adipocytes and trypanosomes, a new paradigm for trypanosomiases – AdipoTryp
Trypanosoma brucei, the causative agent of HAT, was believed to spread exclusively in the fluids of its mammalian host. Breaking with this dogma, we recently shown that most parasites reside in the extravascular compartment, in particular the skin and adipose tissue, where they are in close contact
Message Passing Iterative Decoders based on Imprecise Arithmetic for Multi-Objective Power-Area-Delay Optimization – DIAMOND
Throughput and power consumption are key challenges for next-generation communication systems. High throughput is required to support the continuously increasing demand of traffic volume, while power consumption incorporates sustainability concerns and is a major constraint in mobile devices. Due to
Membrane microdomain HIR proteins: control of iron uptake machinery and new functions in Arabidopsis – NUTRIR
The main objective of the NUTRIR project is to develop a new area of research aiming at better understanding the function of HIR proteins and membrane nanodomains in plants. The first objective is to: (i) characterize the small Arabidopsis HIR protein family (HIR1-HIR4) at the cellular level in t
Membrane for prOtein Separation with designed Architecture of bioInterface at nanosCale – MOSAIC-3D
This project involves a collaboration between the R&D Center for Membrane Technology in Taiwan and the Laboratoire de Génie Chimique in Toulouse (France). It aims at designing a new process for the ultra purification of platelet-derived growth factor (PDGF), a very promising drug which has to be ext
Mega Array of Microphones for the Identification of Environmental aeroacoustic Sources – MAMIES
The objective of the MAMIES project is to develop a new methodology for identifying aeroacoustic sources in wind tunnels. This type of sources, resulting from the interaction of a flow and an obstacle, is at the origin of noise emissions in the environment, for example for transport or certain noise
Mechanisms of mucus transport and bronchial obstruction in COPD – BronchoClogDrain
Bronchial mucus is a hydrogel secreted at the surface of the bronchi to protect them from inhaled contaminants. It is continually transported by the collective beat of cilia that cover the bronchial epithelium, and by cough, a violent air flow capable of dragging mucus plugs away. In COPD, expected
Mechanisms and contribution of Musashi-mediated control of cell wall polysaccharide synthesis in plants – MusaWall
As the main constituent of the terrestrial plant biomass, lignocellulose represents a huge reservoir of fixed carbon and a renewable raw material that is essential for human usages. Lignocellulose biomass enclosed within secondary cell wall (SCW) is mainly composed of cellulose, hemicellulose and li
Mechanics of ESCRT-III catalyzed membrane fission – ESCRTfission
The structural and functional basis of ESCRT-III membrane remodeling is poorly understood. To provide more insight we propose to pursue the following three objectives: 1. The first objective is to solve the structure of the repeating unit of the 40Å-wide ESCRT-III filaments at high resolution, whic
Mechanical Properties of Granular Metamaterials – MICROGRAM
Granular materials surround us more than any other. They cover 80% of the planet, are omnipresent in industry, and the energy we use to produce them exceeds the energy we consume for transportation. Moreover, these materials have the unique characteristic of behaving both as solids, liquids, or gase
Matériaux semiconducteurs MXene/organique hybrides pour des dispositifs électroniques à mobilité élevée – MX-OSMOPED
The proposed project will couple delocalized-state charge-carrier transport in MXenes and in state-of-the-art organic semiconductor crystals (OSCs) to realize high-speed electronic devices fabricated by printing of MXene/OSC blends. We will synthesize inks comprising MXenes and OSCs, which will allo