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Mitochondrial and protease dysfunction in progeroid Cockayne syndrome cells and during age-associated processes – CS_AGE
We study the underlying mechanism of the altered pathway that we identified in CS cells, where oxidative and nitrosative stress (ROS/RNS) promotes overexpression of the HTRA3 protease, which results in the degradation of the key mitochondrial DNA polymerase POLG1 responsible for replication of the o
Minimization of water consumption in agro-food industries by developing a combined approch integrating Water Footprint and Pinch methods – MINIMEAU
In a context of increasing pressure on water resources in France, sustainable access to quality water has become a vital issue for most food industries (FFIs), which consume it for a wide variety of purposes: from ingredient water to cleaning water, not forgetting water used in heat transfers. Most
Microtubule lattice renewal organizes the neuron – MicRON
A unique cytoskeletal architecture allows neurons to establish a complex and polarized arborization, and to maintain it for decades while ensuring the adaptation necessary for cognitive processes. Microtubules are dynamic polymers of tubulin that form tracks for the long-range transport of neuronal
Microstructure and mechanical properties of polycrystalline nickel-base superalloys of the aerojet engines of the future – TOPAZE
The French group Safran is one of the world leaders in the field of superalloy metallurgy and processing. This position must be defended in a context of strong international industrial competition. In this very high-tech field, industrial competitiveness is closely related to advances in scientific
Microscale spatiotemporal investigation of multi-species electroactive biofilms using optical microfluidic platform – MICROBE
The MICROBE research project is a fundamental scientific project in which we plan to clarify at the microscopic level a whole host of grey areas concerning the fundamental processes and mechanisms responsible for the formation and evolution of electroactive biofilms on the surface of electrodes. Key
Microfluidic devices for the sequential reduction of CO2. – MF-CO2
The objectives of this project are the following: i) development of microreactors to perform electrocatalytic reactions under microfluidic conditions. ii)The synthesis of formaldehyde par sequential reduction of carbon dioxyde into carbon monoxide and the subsequent conversion of carbon monoxide i
Microcrystalline SiC/Si3N4 matrix composites for high temperature applications thought a PIP-CVI hybrid process – MATRIX
To face the energy, environmental and economic challenges of air transportation, significant efforts are devoted to the next generation of aircraft turbojets, particularly in the field of advanced materials and their elaboration processes. The main objective is a decarbonisation of air transportatio
Microbubbles Engineering for Drug Delivery-assisted by Ultrasound – MEDDU
Despite tremendous efforts to develop drug delivery systems, therapeutic index and selectivity toward diseased tissue remain very low. The lack of selectivity often results in high toxicity. The use of ultrasounds coupled to the gaseous microbubbles is promising approach to deliver and reach with n
Methods and tools to optimize planing, design, construction and operation of structural covers over transportation infrastructures in urban areas – CANOPEE
Road and railway infrastructures in urban contexts generate visual, acoustic and atmospheric pollution, as well as deep disconnection within urban structures. To compensate for this issue, infrastructure covers are being developped, without any «doctrine« or specific rules to comply with. This rese
Metal Organic Thiolate Coordination Polymers as Innovative Thermoelectric Materials – MOTIC
The chemistry of coordination polymers (CPs) opens up great perspectives for the development of new materials such as in the field of electronics and in energy-harvesting for the recycling of waste heat by thermoelectric effects. These materials consist of an organic matrix crossed by electrical con
