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Structure and function of the cellular target of the anti-Shiga toxin drug candidate Retro-2.1 – SMERSEC
The new chemical entity Retro-2 has a remarkable capacity to protect cells and mice from Shiga-like toxins, ricin, and a number of viruses, without toxicity. The optimized analogue Retro-2.1 is being developed as a drug candidate to prevent the hemolytic and uremic syndrome, a deadly complication of
Valorization of CO2 through BIOMethanation and INTENSification of gas-liquid mass transfer – BIOMIntens
In the light of CO2 valorization and further reduction of greenhouse gases emissions, the BIOMIntens project aims at intensifying the biological methanation process (BIOM), which itself constitutes a building block of the Power-to-Gas strategy platform for the long-term and seasonal electrical energ
Towards clinical investigation on the use of Mineralocorticoid Receptor Antagonist for wet Age-Related Macular Degeneration – MR-A-MD
Strategies that aim at extending the duration of anti-VEGF effects (gene therapy, small antibodies, implantable reservoir) will not benefit to all patients because VEGF is not the only molecular target in AMD31. MR-A-AMD aims at validating that MR pathway is a novel and pertinent target to be tested
Evaluating and managing the migration of contaminants from cellulosic materials – FoodSafeBioPack
The FOODSAFEBIOPACK project offers THREE significant contributions. (1) The transfer conditions will be exhaustively qualified by food type and modality for packaged foods sampled from the market by using a new design of migration cells enabling humidity control, freezing, and oven heating. (2) The
Heat Management in the Ballistic Limit at the nanoscale – HANIBAL
The manipulation of heat fluxes is possible by acting on the transport of phonons at the nanoscale in thermal metamaterials. This is one of the major challenges of the current small-scale energy management. In order to demonstrate innovative effects involving large phonon mean-free-paths and long ph
Yarrowia lipolytica oleochemicals based on odd chain fatty acids – YaLiOl
The objectives of the YaLiOl project are to: 1) to advance the engineering of Y. lipolytica for the production of odd-chain fatty acids (OCFA); 2) to develop a fermentation medium based on sugar beet molasses; 3) recovering the OCFAs, characterizing them, and transforming them into oleochemical
The return to an aquatic life, the evolution of propulsive efficiency & biomimetics – DRAGON2
The return to an aquatic life has shaped many organisms and profoundly impacted fossil and extant marine ecosystems. Understanding how terrestrial organisms adapted to a drastically novel environment poses fundamental challenges, however. Indeed, in most lineages this major transition entailed deep
AUTOmated exploration of MATerials for PROton-conducting solid oxide CELLS – AUTOMAT-PROCELLS
Solid Oxide Fuel/Electrolysis Cells are electrochemical devices based on ceramics which operate at high temperature, typically 600-800 °C. This high temperature is needed to ensure fast diffusion and reaction rates i.e. to allow for high power efficiency. Unfortunately, coupled with extreme operatin
Schrödinger problem, optimal transport and stochastic calculus – SPOT
The goal of this project is to study the most probable trajectory followed by an interacting particle system when a spontaneous fluctuation is observed. In its most basic form, this is known as the Schrödinger problem. In their general form, the problems at the heart of this project are formulated
Free space Isomorphisms and Isometries – FRII
This project aims at substantially advancing the knowledge about Lipschitz-free spaces and their applications to metric geometry and to functional analysis. For a metric space (M,d) the free space F(M) is a Banach space that is built around the metric space M in such a way that M is isometr
