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Understanding the PROtectiVe Inflammation in DiabEtes – PROVIDE
The overall objective of the proposed project is to reveal the physiologic role of inflammation dependent of IRF5 pathways in the adaptation to metabolic stress linked to T2D. Understanding the physiological and the pathological role of the immune system may allow designing personalized treatments promoting a beneficial immune status in patients with T2D.
Towards the prevention of vascular dysfunctions and the targeted delivery of drugs through the endothelia – TransEndotheliaTunnel
We have discovered a new mode of opening of transendothelial macroaperture (TEM) tunnels, which is driven by the relaxation of the actomyosin cytoskeleton leading to a cellular dewetting phenomenon. We identified key biochemical and physical parameters withstanding cycles of TEM opening and closure. We aim at identifying molecular players that control extension/resealing of the TEMs. The cellular dewetting hypothesis implies a membrane curvature-sensing mechanism that we propose herein to unveil
Tailoring exercise with muscular contraction modulation: development of an innovative hybrid ergometer – EXO-MODE
metabolic responses between concentric and eccentric muscle action. However there are growing evidences that
Study of a putative novel respiratory center – Phox2RESP
This project aims at deciphering the function of a new group of putative respiratory neurons in the hindbrain of the mouse: peri-trigeminal neurons (Peri5). Using genetic tools derived from developmental studies, we will map the connectivity of the Peri5 neurons, target specific mutations to them and characterize their function in reduced ex vivo and in vivo preparations.<br /><br />
Splice switching methods for the treatment of Pompe disease – POMPE
therapy efficiency on differentiated human skeletal muscle. The herein proposed research will advance this
Social dimension of primates’ peripersonal space – MySPACE
The aim was to shed new light on the social modulation of space close to the body, by exploring its behavioral determinants and neural markers. In our social world, a comfort zone is necessary to regulate the distance between oneself and others and to avoid discomfort. Our hypothesis was that the space of communication and interaction with social information close to the body reflects an integration of our goals and our internal state.
SUStainable production of HIgh quality aquaculture FISH using innovative tools and production strategies and integrating controlled slaughter and novel processing methods and cold chain management – SUSHIFISH
egg/larval imprinting strategies to improve growth and muscle quality and by monitoring and reducing chronic
Regulation of myogenesis by the extracellular matrix - application to the use of matrix scaffolds for reparation of large skeletal muscle lesions – Myo-MECa
Skeletal muscle regenerates after an injury thanks to the muscle stem cells as well as to neighboring [...] proposal aims at repairing large muscle injury via the adjunction of muscle-derived matrix biomaterial, which [...] involved in muscle regeneration. Literature shows that ECM plays an important role in muscle regeneration
PATHOPHYSIOLOGY OF THE COSTELLO SYNDROME: STUDY IN MICE AND CELL MODELS – COSMIT
intellectual deficit and skin abnormalities, with muscle and heart alterations. Our aim is to elucidate [...] explored the mice and found an alteration of muscle strength, locomotor activity, heart function,
Muscle stem cell quiescence and heterogeneity – SatNet
skeletal muscle to regenerate depends on satellite cells, the quiescent stem cells of the adult muscle. Quiescent [...] proliferate and generate new muscle fibers. Other cell populations in the muscle like interstitial, microvascular [...] activated in response to injury or in degenerative muscle diseases. During regeneration, a proportion of