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Going beyond the limits of myoelectric upper-arm prostheses: phantom hand movements for natural control – PhantoMovControl
of functionally distinct muscle volumes within the same muscle, i.e., muscle volumes that are distinctly [...] associated to specific activities of residual limb muscles according to the type of performed phantom movement [...] use these patterns of activation of the distinct muscle volumes to make the prosthesis mimicking the executed
Social dimension of primates’ peripersonal space – MySPACE
The aim was to shed new light on the social modulation of space close to the body, by exploring its behavioral determinants and neural markers. In our social world, a comfort zone is necessary to regulate the distance between oneself and others and to avoid discomfort. Our hypothesis was that the space of communication and interaction with social information close to the body reflects an integration of our goals and our internal state.
Study of a putative novel respiratory center – Phox2RESP
This project aims at deciphering the function of a new group of putative respiratory neurons in the hindbrain of the mouse: peri-trigeminal neurons (Peri5). Using genetic tools derived from developmental studies, we will map the connectivity of the Peri5 neurons, target specific mutations to them and characterize their function in reduced ex vivo and in vivo preparations.<br /><br />
Design of a novel class of biodegradable and functionalized polyesters for cardiac application – NANOCARDIOROP
cross-linked polyesters to promote contractile muscle formation limiting the remodeling process and therefore
FGF21 links hepatic ChREBP and PPARa to systemic glucose control – Hepatokind
beneficial action in peripheral tissues (skeletal muscles, white and brown adipose tissue) and in pancreatic
Microsystem including transducers based interpenetrating polymer networks – MicroTIP
New generation polymer transducers for microrobotic applications
HUMAn Neuromuscular Integrative System for drug discovery – HUMANiSM
disease-specific human motoneuron- muscle co-cultures with muscle cells to study pathologies and applications [...] progressively blocks the control and the force of muscle voluntary movement by affecting motoneurons and [...] induced Pluripotent Stem Cells (iPSC) and human muscle cells to form numerous NMJs, a cell model which
IDENTIFYING THE DRIVERS OF LUNG RESIDENT VASCULAR PROGENITORS RECRUITMENT CONTRIBUTING TO PULMONARY ARTERIAL HYPERTENSION DEVELOPMENT – PAHVAP
remodeling during PAH. Our results show that smooth muscle cells (VSMC) of small pulmonary vessels differentiate
Towards the prevention of vascular dysfunctions and the targeted delivery of drugs through the endothelia – TransEndotheliaTunnel
We have discovered a new mode of opening of transendothelial macroaperture (TEM) tunnels, which is driven by the relaxation of the actomyosin cytoskeleton leading to a cellular dewetting phenomenon. We identified key biochemical and physical parameters withstanding cycles of TEM opening and closure. We aim at identifying molecular players that control extension/resealing of the TEMs. The cellular dewetting hypothesis implies a membrane curvature-sensing mechanism that we propose herein to unveil
PATHOPHYSIOLOGY OF THE COSTELLO SYNDROME: STUDY IN MICE AND CELL MODELS – COSMIT
intellectual deficit and skin abnormalities, with muscle and heart alterations. Our aim is to elucidate [...] explored the mice and found an alteration of muscle strength, locomotor activity, heart function,