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In vivo analysis of muscle stem cells vascular niche – MyoStemVasc
ns with muscle stem cells during the regeneration of skeletal muscle and in diseased muscle. [...] Skeletal muscle regenerates after injury, due to the satellite cells (SCs), the muscle stem cells that [...] that vascular smooth muscle cells and pericytes regulate SC quiescence during muscle post-natal growth.
Dysfunctions of Human Muscle Stem Cells in Sepsis – PUSHUPS
Indeed in healthy situation muscle regeneration is very efficient. Upon muscle injury they are activated [...] of acquired neuromyopathy, meaning an important muscle weakness which can be disabling for up to 5 years [...] hospitalization. Many studies showed that this muscle weakness involved 1) the impairment of muscular
Translational optimization of AAV vectors to cure GSDIII – TRACeGSDIII
vectors specific for muscle targeting, we demonstrated a complete rescue of the muscle strength impairment [...] n is primarily due to its absence in liver and muscle. In particular, during childhood, the disease is [...] episodes becomes less severe and a generalized muscle weakness and cardiomyopathy appear. Cirrhosis and
In vivo AAV-based gene transfer to the muscle: Deciphering host immune responses – TOLGEN
great promise. rAAV-mediated gene transfer in the muscle is promising for a variety of clinical applications [...] these promising achievements, rAAV delivery to the muscle can induce transgene product rejection in large [...] tolerance through the participation of the skeletal muscle and potentially the liver. TOLGEN project aims
Signaling and epigenetics during skeletal muscle differentiation: Regulation of histone and non-histone lysine methylation by the Wnt pathway – MuSiC
study skeletal muscle regeneration. This process is mediated by adult muscle stem cells (muscle satellite [...] during muscle terminal differentiation. 2)- Investigate the function of SETDB1 during muscle tissue [...] cytoplasmic localizations, which is modulated during muscle differentiation by the Wnt/beta-Catenin pathway
Injectable and haemostatic hydrogel for guiding and reconstruction of deep wounds – GELIHPARBAL
proliferation and differentiation of muscle stem cells and in inducing muscle regeneration; 3) develop injectable [...] decrease bleeding immediate threat while improving muscle repair and functional skin healing. A new avenue [...] wounds, while (2) providing a specific guidance of muscle and skin repair. A major innovation will be
Pediatric and Adult Plasticity of Intestinal SMCs – PAPIS
dedifferentiation (plasticity) of the GI smooth muscle, our team demonstrated that RNA-binding protein [...] protein essential for immaturity of GI smooth muscle cells (SMC) is involved in the SMC plasticity process [...] pathways during the remodeling of digestive smooth muscles in digestive motility disorders in order to develop
Ribosomal and small non-coding RNAs in oculopharyngeal muscular dystrophy – riboOPMD
late onset of progressive weakening of specific muscles leading to ptosis (eyelid drooping), dysphagia [...] leading to its aggregation in nuclei of affected muscles. There is currently no pharmacological treatment [...] mammalian alanine expanded-PABPN1 (PABPN1-17ala) in muscles. This model reproduces the characteristics of the
Antigenic targets and animal model in immune necrotizing myopathies – CAMANAI
define the T and B cells targets in an autoimmune muscle disease and to develop a mouse model of the disease [...] réductase (HMGCR) antibody (Ab). It is rare chronic muscle disease. This disabling setting justifies immu [...] years, permitting in the best case to stop the muscle damages. There is a strong genetic background since
Development of multi-targets antidotes against organophosphorus nerve agents – Multidote
intoxicated person (by paralysis of the respiratory muscles). Based on the results of the previous projects [...] nicotinic effects (ie paralysis of respiratory muscles) and the muscarinic receptors (mAChRs) responsible