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Regulation of myogenesis by the extracellular matrix - application to the use of matrix scaffolds for reparation of large skeletal muscle lesions – Myo-MECa
Skeletal muscle regenerates after an injury thanks to the muscle stem cells as well as to neighboring [...] proposal aims at repairing large muscle injury via the adjunction of muscle-derived matrix biomaterial, which [...] involved in muscle regeneration. Literature shows that ECM plays an important role in muscle regeneration
Muscle stem cell quiescence and heterogeneity – SatNet
skeletal muscle to regenerate depends on satellite cells, the quiescent stem cells of the adult muscle. Quiescent [...] proliferate and generate new muscle fibers. Other cell populations in the muscle like interstitial, microvascular [...] activated in response to injury or in degenerative muscle diseases. During regeneration, a proportion of
Going beyond the limits of myoelectric upper-arm prostheses: phantom hand movements for natural control – PhantoMovControl
of functionally distinct muscle volumes within the same muscle, i.e., muscle volumes that are distinctly [...] associated to specific activities of residual limb muscles according to the type of performed phantom movement [...] use these patterns of activation of the distinct muscle volumes to make the prosthesis mimicking the executed
HUMAn Neuromuscular Integrative System for drug discovery – HUMANiSM
disease-specific human motoneuron- muscle co-cultures with muscle cells to study pathologies and applications [...] progressively blocks the control and the force of muscle voluntary movement by affecting motoneurons and [...] induced Pluripotent Stem Cells (iPSC) and human muscle cells to form numerous NMJs, a cell model which
Development of in vitro micropatterned neuromuscular junctions – MIMETiC
which the activity of spinal motoneurons controls muscle contraction or relaxation during movement. As existing [...] explore electrophysiological features of motoneuron-muscle synaptic transmission and/or to evaluate new drugs
Crosstalk of Glucocorticoid Receptor and AMP-activated protein Kinase in macrophages during inflammation and tissue repair – GR-AMPK
activation is required for a proper repair of damaged muscle by inducing an anti-inflammatory phenotype in [...] evidence that i) GC-treated macrophages influence muscle repair dependent on AMPK in vitro, that ii) an [...] inflammation model (non sterile inflammation) and in a muscle repair model (sterile inflammation) how AMPK c
Microsystem including transducers based interpenetrating polymer networks – MicroTIP
New generation polymer transducers for microrobotic applications
Identification of biomarkers of beta-cell stress and inflammation by exploring inter-organ communication inpreclinical models of obesity and type 2 diabetes – betadiamark
glucose uptake and utilization by liver, fat, and muscles. The balance between insulin secretion and action [...] tissue (visceral and subcutaneous depot), skeletal muscle (soleus and tibialis anterior) will be isolated
PATHOPHYSIOLOGY OF THE COSTELLO SYNDROME: STUDY IN MICE AND CELL MODELS – COSMIT
intellectual deficit and skin abnormalities, with muscle and heart alterations. Our aim is to elucidate [...] explored the mice and found an alteration of muscle strength, locomotor activity, heart function,
Splice switching methods for the treatment of Pompe disease – POMPE
therapy efficiency on differentiated human skeletal muscle. The herein proposed research will advance this