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Dynamic assembly of aromatic oligoamide foldamers for stabilizing protein-protein interactions – FOLDynamic
Combining the self-assembly properties of aromatic oligoamide foldamers into double helices in water with their protein surface recognition properties via their proteinogenic side chains to ultimately stabilize heteromeric protein dimers.
Muscle cell type evolution and development – MYODEVO
In the hundreds of millions of years of animal evolution since the cnidarian lineages diverged from those of the bilaterian animals, body plans, anatomies and behaviors have diversified widely, but in all cases these features are underpinned by complex neuromuscular systems. To what extent these systems can be traced back to ancestral neuromuscular systems in a common ancestor, or arose convergently, is a key question in animal evolution.
Generation and characterization of 3D organoid models as tools to identify the biological underpinnings of therapy resistance and relapse in pediatric sarcomas – CHILD-SARC
Despite the use of a multimodal treatment, survival rate for pediatric sarcomas has come to a standstill for the last decades. We then crucially need to learn more about pediatric cancers specificities to discover the next generation of oncogenic processes to develop more effective and less toxic treatments adapted to young patients.
Dynamic Versatile Semantics – DYVERSE
The objective of DyVerSe is to provide better tools for a dynamic description of programs. This representation must handle rich combinations of computational effects: higher-order, shared memory concurrency, probabilistic choice, etc. It must also allow us to link earlier semantic development for specific effects, which have until now remained separate.
Rainfall Wind Turbine or Turbulence – RW-Turb
RW-Turb relies on the expertise of HM&Co in measurement and modelling across wide range of spatio-temporal scales of atmospheric turbulence and rainfall to quantify the impact of the latter on wind power production. <br />This project benefits from an industrial partnership with Boralex, a wind power producer.<br />RW-Turb will open new paths to improve nowcasts of power production, a major challenge in a framework of increasing use of renewable energies in France and Europe.
The construction of “surveyed public opinion” in France and Germany – CosPo
The construction of “surveyed public opinion” in France and Germany
Bridging geohysics and MachinE Learning for the modeling, simulation and reconstruction of Ocean DYnamics – MeLODy
Bridging geophysics and MachinE Learning for the modeling, simulation and reconstruction of Ocean DYnamics
Cross-talk between the CXCL12 chemokine receptors CXCR4 and ACKR3: contribution of oligomers populations to receptors signaling and function – OCHRE
unique binding/signaling entities, the original features of which will be further deepen. To investigate [...] comprehensive map of the structural and biological features of CXCR4/ACKR3 oligomers that will benefit to
Analog Computation with Photonic Spiking Nodes – Anaconda
from biological neurons. Each artificial neuron features multiple inputs and one output, which together [...] ic test system in view of implementing a full-featured, ultrafast all-photonic spiking neural network
Light water, heavy water, and sodium chloride aqueous solutions under extreme conditions to shed light on water anomalies and structural properties – H2D2OX
Water is the most anomalous liquid and some of its properties have yet to be measured, especially under extreme temperature and pressure conditions.