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Leptin signaling and RNA m6A methylation in acute lung injury: pathways to microvascular barrier protection and therapeutic targets – LAMPS
Acute respiratory distress syndrome (ARDS) is a complex and severe syndrome characterized by an acute lung injury (ALI) without curative treatments. Disruption of lung microvascular barrier and dysregulated inflammation are the central pathophysiological features of ALI common to all ARDS etiologies
Emergence dynamics of Sarbecovirus coronaviruses : Zoonose mecanisms. – EmerCoV
The 21st century began with a wave of emerging epidemic infectious diseases, of which COVID-19 is considered one of the most serious, with a devastating impact worldwide. Seventeen years after the emergence of SARS-CoV from 2002-2003, in 2019, it is again a Betacoronavirus Sarbecovirus (SARS-CoV2, t
Fe-S clusters as essential cofactor of Coronavirus replication – CoV-FeS
Replicating and maintaining genome integrity is an upmost task for all organisms. To replicate their exceptionally large genome, Coronaviruses (CoVs) employ a unique and sophisticated RNA-synthesis and correction machinery, composed of, at least, the RNA-dependent RNA polymerase (RdRp, nsp12), the h
Bioinspired scaffolds to fight human coronaviruses – CoroNat2
The COVID-19 pandemic caused by SARS-CoV-2 has highlighted the urgent need to identify antiviral compounds against human coronaviruses (HCoV). The multidisciplinary CoroNat2 project involves 4 complementary teams, each with pre-existing technical expertise in virology, phytochemistry, chemistry and
Coronavirus membrane pores – MemPoco
Coronaviral infection involves remodelling of the host endoplasmic reticulum (ER) to form double membrane vesicles (DMVs); compartments that house the viral replication complexes and RNA. A recent study identified a transmembrane pore that crosses both membranes of the DMV, providing a point of exch
Mechanisms of Action of anti-SARS-CoV-2 – MACoVA
Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) contribute to vaccine efficacy and are used as therapy against Coronavirus Disease 2019 (COVID-19). They act by neutralizing viral replication, but also by recruiting immune effector mechanisms. These so-called non-neutr
New strategies for decoding cyclophilin biological functions – CYP-TAC
Cyclophilins are a family of proteins that catalyzes the cis/trans isomerization of peptide bonds at proline residues, which facilitates protein folding. CypA, the most abundant cyclophilin isoform, has been described as a key player in viral infection for viruses such as HCV, dengue virus, coronavi
Role of type I Interferons and plasmacytoid dendritic cells in the lung immunopathology caused by respiratory viral infections – RIPIREVI
Type I interferons (IFN-I) are key cytokines in vertebrate antiviral defense. However, if excessive or chronic, their production can contribute to the pulmonary immunopathology caused by respiratory infections with influenza (Flu) or coronaviruses. Treatment with glucocorticoids induces a broad immu
Wearable Nano-Opto-electro-mechanic Systems – SNOW
Motivation: Health and fitness wearables present mobile solutions for ICT in public wellbeing by providing personal remote control and clinical intervention through telemedicine networks. Due to their noninvasive and continuous vital sign monitoring, wearables are incorporated in several studies t
Artificial-Intelligence-based Methods for Nanobody Design – ANDES
ANDES aims at developing and experimentally validating new computational methods for nanobody design, with a large spectrum of applications (therapies, diagnosis…) in order to have efficient technological solutions, ready to react very quickly and to face the emergence of new viruses. Our ambition l
