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DYRK-DOWN: DYRK1A, a dosage sensitive gene at the crossroad of development and brain function for treating Down syndrome – DYRK-DOWN
DYRK1A during development and brain function is needed for treating Down syndrome with a DYRK1A inhibitor [...] mechanisms involved remain to be elucidated. DYRK1A encodes a protein kinase with many substrates involved [...] of L41 as a pharmacological tool to identify molecular and cellular events following DYRK1A inhibition
Menage a trois: a third, feminising sex chromosome. Evolutionary consequences and relevance to mammalian sex determination genetics – SEXREV
pygmy mouse Mus minutoides that harbours a third sex chromosome: a feminising variant of the X, named X* [...] chromosome transmission, a hotly debated topic. This will be the first study on a model with such variety [...] mammalian sex determining pathway. A crucial development of such a study concerns its possible application
Organotitanium (II): a versatile reagent for a rapid access to [5-7] bicycles and highly functionalized systems – TVA
should offer a straightforward access to a wide molecular diversity. As an ultimate goal, a diastereoselective [...] d vibsane and [5-7]-fused guaiane frameworks. As a proof of concept, the ability of titanium (II) to [...] synthesis of various other natural backbones possessing a seven-membered rings and readily applied to the total
A Multidisciplinary Approach for the design of a predictive tool in the Rheology of non-Brownian suspensions. – AMARheo
some NBS can be explained by a transition from a non-frictional flow to a flow where the frictional contacts [...] such a decrease in the friction coefficient is expected in the case of a contact involving one or a few [...] NBS in order to build a general framework for NBS rheology and to develop a numerical tool that allows
Chemically Architectured MEtallic aLloys, towards a new strengthening mechanism – CAMEL
CAMEL: Chemically Architectured MEtallic aLloys, towards a new strengthening mechanism Keywords: Materials [...] alloys (HEA). We propose a multi-scale experimental approach combined with a macroscopic simulation of [...] fluctuations of chemical composition are proposed as a new strengthening mechanism. The objectives are to
LoToReg: Local Topology and global Regulation, modeling of a dynamic and multiscale coupling – LoToReg
DNA topology, i.e., torsional deformation experienced by the double-helix, is an ubiquitous feature both in prokaryotes and eukaryotes. In bacteria, it is controlled by conserved topoisomerase enzymes, and is involved in an ancestral double-sided coupling with transcription. Relating the structure and function of the genome, it acts as a basal and global transcription factor that remains poorly understood. Characterizing this mechanism is thus a fundamental problem in bacterial genetics.
Dissection of the cellular processes during heterologous protein production in P. putida – or how much is a protein? – CHEAP
In this project the following questions are tackled: What is the cost for the production of a specific protein? Where are the bottlenecks during heterologous protein production? Can this information be generalized and eventually predicted? Our vision is to develop a toolbox that allows us to predict the optimal environment for a specific gene or, eventually, also for a small pathway in order to achieve the best performance possible.
Role of the histone variant H2A.Z in phytopathogenic fusaria – HISTOVAR
Role of the histone variant H2A.Z in phytopathogenic fusaria
Galen in Arabic. More than a translation. – GAIA
“Galen in Arabic – More than a Translation” aims at investigating the crosspollinations between three intellectual strands of the Islamicate world in the 9th and 10th centuries: the reception of the Greek medical tradition as expressed in the writings pertaining to the Galenic tradition, early Arabic philosophy (falsafa) and early Islamic theology (kalam). Our hypothesis is that the intellectual debates that took place within the Islamicate world impacted the reception of this tradition.
Methods for discovering SNP Combinations Associated with a PHEnotype, from genome-wide data – SCAPHE
Genomic differences explain in great part why patients experience disease differently. However, current methods to discover associations between single nucleotide polymorphisms (SNPs) and a phenotype account for little of these differences. SCAPHE builds on the hypothesis that this is due to the effect of non-additive interactions between SNPs, together with a lack of robustness stemming from the relatively small sample sizes, which can be alleviated by integrating biological networks.