Search for a funded project
Development and commercialization of optimal microscopes for membrane potential optical recording – Voltimagmicro
can be commercialized, under a licence agreement, by a small company with a long history in this type of [...] prototypes: A) a two-photon microscope to resolve voltage signals from sub-micron structures and B) a microscope [...] of this important market niche, a product that is both flexible for a particular experimental investigation
Preclinical analysis of the efficacy of a LIM Kinase inhibitory compound for primary and metastatic cancer chemotherapy – LIMINIB
promising, showing a good therapeutic efficacy together with a good tolerance. A study, which aims to [...] ed that the level of cofilin activity, a protein that plays a central role in actin microfilaments dynamics [...] last step of a cascade that regulates actin dynamics. It has been shown that LIMK plays a central role
Impact of new protein on the assessment of cardiovascular risk – CARDIF1
preliminary data showing a positive correlation between circulating IF1 and HDL levels in a cohort of 275 male [...] discovery of a new way increasing functional HDL, for the development of new drugs as a treatment for [...] its major protein component apolipoprotein (Apo) A-I are strongly inversely associated with cardiovascular
Innovative technology for stem cell survival and maintenance in 3D culture – 3D +
laboratory by Elise Demange, a PhD student, motivated by the creation of a start up. The valorisation team [...] cell types. The 3D cell culture technology permits a more realistic environment in comparison with that [...] behavior in addition to intercellular interaction. A collaboration realised with Pr Didier Le Cerf team
Glycan microarrays of cell wall polysaccharides in functional genomics – WALLARRAY-II
2008. In this framework, the project was funded for a feasibility study over one year. The obtained results [...] the interplay of the cell wall glycome (defined as a set of carbohydrate structures present in the cell [...] ydrate interactions. The project brings together a diverse set of established novel technologies which
A high power bipolar Li-ion cell for HEV applications – Green Lion®
Lion® project is dedicated to the valorisation of a specific Li-Ion technology developed by CEA and combining [...] The project especially aims the development of a Li-ion bipolar cell 15 Wh- 24V (which consists on [...] bipolar design), previously designed by the CEA in a project funded by ADEME and named “PowerSafe”. Through
Preclinical study of a new innovative peptide therapy for a causative treatment of sepsis – LR17 peptide therapy in sepsis
Sepsis exemplifies a complex clinical syndrome that results from a harmful and damaging host response [...] , etc), acting like a decoy receptor and competing against TREM-1 receptor. As a result of this activity [...] (TREM-1). Indeed, TREM-1 and TLRs appear to cooperate in a synergistic way. The role of TREM-1 as an amplifier
Study and fabrication of Membrane-electrodes Assembly by plasma Directe deposition on high perfomance electrolyte membrane. – AMADEUS
concerned by plasma CCM and CEA is owner of a patent on a high performance membrane (patent WO2009000779) [...] reliability of a compact AME, eventually convenient for miniaturization. This project requires a rigorous work [...] environnementally friendly energy sources is matter of a great attention. In the field of fuell cells, it is
Improvement of assisted reproductive techniques by phospholipase A2: the primate assay. – LUTINFER
only 10% of embryos transferred give rise to a baby. In 1992, a new technique arose, called ICSI (for Intra [...] the fertilization rate and promotes a normal embryo development. A patent, called « Fertilization modulation [...] confirm these results in a primate model, in order to bring this discovery to a potential human drug level
Degradation and transfer of polyacrylamide based floculents in sludges and industrial and natural waters - Potential impact on aquatic ecosystem – AquaPOL
question of flocculants innocuousness is now arising as a new environmental issue. The flocculants which are [...] calling into question are composed of polyacrylamide, a polymer synthetised from acrylamide and acrylic acid [...] residual amount of acrylamide which is classified as a carcinogenic (level 2), mutagenic (level 2) and reprotoxic