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The duo O-GlcNAcylation-Wnt/ß-catenin pathway, a promising therapeutic target for the treatment of intervertebral disc degeneration and osteoarthritis – ArNAc
The most common degenerative joint diseases are intervertebral disc disease (IVDD) and osteoarthritis (OA). These two chronic conditions, which are both characterized by pain and an absence of a known cure, are highly prevalent in modern societies, particularly among the elderly and individuals with
Resourceful Enzyme-Activated Compounds based on Alkoxyamine scaffold for the Treatment of parasitic diseases – REACT
Neglected tropical diseases (NTDs) affect millions of people worldwide, mainly in tropical and subtropical regions. These diseases, caused by a variety of pathogens and toxins, have serious health consequences as well as significant social and economic impacts. They mainly affect poor communities. I
Hydro-Acoustic Recording and Multidisciplinary Observations linked by Numeric Integration for Eruption monitoring – HARMONIE
HARMONIE aims to enhance our understanding of the 2018-2021 Fani Maoré submarine volcanic eruption near Mayotte, Mozambique Channel. Submarine eruptions pose significant challenges due to limited access to eruption sites and high-resolution data. The Fani Maoré eruption provides a unique opportunity
The Sempervivum genus, a model for the characterization and the development of original natural deep eutectic solvents (NaDES) – SemperDES
Based on the IdEx NADESGENE and HeliDES obtained in 2021 and 2024 and on encouraging preliminary results, the biosinpired project SemperDES brings together academic and indutrial partners in natural products and extractive chemistry, physical chemistry, toxicology and biotechnology in order to cover
Interdisciplinary and multi-tracer scientific exploitation of the GEOTRACES GEOVIDE cruise results, through modelling and observations – GEOMOBS
The scientific analysis of trace elements and isotopes (TEIs) data in the ocean, obtained through GEOTRACES cruises, is often conducted using simplified tools such as box models, one-dimensional models, or optimal multiparametric analyses. These approaches generally do not allow for the full integra
Holistic and Generalizable Solutions for Bias Mitigation in Face Recognition – GOOD-BIAS
Bias in AI results from systematic discrimination in artificial intelligence systems. Often, this stems from non-representative training data or societal biases reflected within even diverse datasets. Such biases can lead to unfair advantages for certain groups, with consequences ranging from hiring
Breathing to Brain Feedback for Recovery during Aversive Learning – Breathing4FearRecovery
This project explores the dual role of breathing in both stress maintenance and recovery following aversive experiences. Our recent findings show that during fear conditioning, mice adopt a 4-6Hz breathing rhythm that sustains freezing behavior, with neuronal oscillations in the olfactory bulb (OB)
TOWARDS THE DETECTION OF EXOPLANET BIOSIGNATURES WITH LARGE AMPLITUDE MOTIONS USING HIGH RESOLUTION SPECTROSCOPY – EXOBIOLAM
The search for life in the Universe is a tremendous motivation for the detection of planets beyond our Solar system. Launched at the end of 2021 the James Webb Space Telescope (JWST) allows us to study the atmospheres of the vast diversity of exoplanets. Following the groundbreaking advancements of
Modeling Safeness: towards Experimental, Ecological and Network-based analyses of intra- and inter-individual Cognitive and Emotional Processes. – SAFE-MOD
Safeness plays a major role in the onset and development of psychopathological disorders (e.g., Mikulincer & Shaver, 2012; Richter et al., 2009). While some theories have been proposed to explain the development of tsafeness, no empirical evidence to date has evaluated the processes involved (e.g.,
Diffusion of High Pathogenicity H5N1 Avian Influenza in wild animal populations: a better understanding for a better mitigation – WILDFLU
Since 2021, highly pathogenic avian influenza clade 2.3.4.4.b H5N1 has affected wild species at unprecedent scales in terms of numbers of species and individuals, and geographic areas. Many of the newly affected species, notably colonial seabirds and marine mammals, share ecological characteristics
