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Building of a diagnostic/prognostic database by high-throughput multiplexed assays for human ERG variant effects – CarDiag
In the French clinical research centers, about 400 natural variants have been discovered that concern the hERG channel. Most of these variants have been classified as VUS (unknown significance) because the structural and functional impact, as well the effect on trafficking, have not been characteriz
Evolution of extreme sea levels in the context of climate change – ClimEx
Climate is changing due to warming, and since the 1950s, many of the observed changes are unprecedented over decades to millennia (IPCC, 2021). Global mean sea level has increased by 0.20 m over the last century, which leads to larger sea level extremes and more flooding. It is then essential to inv
The Behavioral and Computational Nature of Range Dependent Decisions – RANGE
Individual decision-making drives major financial, social, environmental and health outcomes. Most choices are made under uncertainty and require continuous arbitrage. Standard economic theory assumes stable, complete and context-invariant preferences defined on an absolute scale of utility. However
Atlas of the Balkan Linguistic Area – ABLA
To obtain an up-to-date and detailed picture of what the Balkans as a linguistic area look like, we propose to create an online database that carefully maps the linguistic features in various languages and dialects and to relate them to the socio-historical information available. Friedman (2021) poi
Ultra Low Power Smart 3D Cochlea – ULP-COCHLEA
Objective 1: Design a bioinspired analog cochlea The objective is to design a bioinspired CMOS cochlea able (like any mammal ear) to convert acoustic analog signals to parallel trains of spikes and bi (multi-channel) naurally to localization. The cochlea will be connected to an existing ULP hydroph
SYnchronized Low power Versatile Acoustic Network Including Artificial intelligence – SylvanIA
Despite ambitious targets at reducing biodiversity loss, assessing these changes remains an epic challenge. A better monitoring of ecosystems remains the only solution. Acoustic passive monitoring is getting popular to sample different groups of vocal wildlife. However these tools remain limited as
Characterization of the mechanisms responsible for Artificial Kidney-Induced Kidney injury after acute kidney failure in intensive care units – MAKIKI
The repetition of acute kidney injury (AKI) episodes is recognized as a major risk factor for chronic kidney disease (CKD). It is therefore crucial for the long-term quality of life of the patients to limit the incidence of AKI and to improve renal function recovery. Renal replacement therapy (RRT)
Analysis of the interplay between digestive microbiota and immune system in the development of rheumatoid arthritis – BactRiA
Background: Recent investigations have suggested a mucosal origin of rheumatoid arthritis (RA) because of its remarkable association with several mucosal inflammatory conditions. These findings are consistent with the hypothesis of a cross-reaction between auto-immune antibodies directed at both mic
CONFLICTS BETWEEN LARGE MARINE PREDATORS AND HUMANS: THE GENESIS AND MANAGEMENT OF PROBLEM INDIVIDUALS – ETHO-PREDATOR
A common misconception is that the emergence of problem animals in populations of large marine predators is the result of external factors that modify the innate, homogeneous behavior of individuals in a given population. Our hypothesis tests the opposite paradigm, which would suggest that, without
Role Of C-di-GMP in the Kinetics of legionella Effector Translocation – ROCKET
Secretion system (SS)-mediated delivery of effector proteins into host cells plays a key role in bacterial virulence. Despite recent progress in the structure-function studies of various SS (e.g. T3SS, T4SS, T6SS, etc.), the signals that activate effector transfer have largely remained a closed book
