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ElectrochemiLuminescence nano-Imaging of Single Entities – ELISE
Electrochemiluminescence (ECL) is the light emission produced by the excited state of a luminophore that has been generated following an electrochemical reaction. It is therefore a hybrid method combining electrochemical stimulation and optical detection. ECL is a powerful analytical technique that is attracting considerable interest in medical imaging and diagnostics. This project combines ECL with superlocalization microscopy for dynamic 3D tracking of individual objects.
Mechanisms controlling Li incorporation and isotope fractionation in CaCO3 minerals – MeLiCa
Mechanisms controlling Li incorporation and isotope fractionation in CaCO3 minerals
Communities dynamics around Fe-oxidizing bacteria in Iron-rich microbial mats: Adjustment to environmental variations – IRONWOMAN
While the iron cycle and its interactions with other biochemical cycles are increasingly being studied, the role of iron-oxidizing bacteria (FeOB), their relationships with other microorganisms in iron-rich mats and how they respond to environmental variations have been sparsely addressed so far. The originality of our approach will be to address these questions, preserving as much as possible the complexity of iron-rich microbial mat ecosystems and the environment in which they develop.
Entrepreneurial fear of failure in times of the Covid-19 crisis: Antecedents, dimensions and consequences – A focus on entrepreneurs in the hotel, restaurant, bar and fitness industries – COVENTFOF
Small businesses in B2C industries have been particularly affected, specifically those that are “store-based” and can no longer welcome customers into their stores due to administrative closures, lockdowns, curfews and subsequent hygiene constraints. The small businesses that today are either closed or in real difficulty are mainly hotels, restaurants, bars and fitness centers. All these businesses are very important to the French economy in terms of dynamism, sales, employment, etc.
Involvement of circulating fibrocytes in pathophysiology and prognosis of COVID-19 pneumonia – FIBROCO
High circulating levels of fibrocytes are correlated to an unfavourable outcome during acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis. COVID-19 pneumonia shares common histological and inflammatory features with ARDS. We aimed to determine the involvement of circulating fibrocytes during the course of COVID-19 pneumonia, and to assess if fibrocytes could be a prognosis biomarker.
Functional aspects and physisopathological impact of intracytoplasmic lipid inclusions in mycobacteria – ILIome
Tuberculosis (TB) caused by the pathogenic bacterium Mycobacterium tuberculosis (M.tb), is the deadliest infectious disease worldwide. Treating TB takes a minimum of 6-9 months. The emergence of drug resistant strains amplifies the incidences of TB, mainly resulting in failure of treatment and death. There is thus an urgent need for novel therapeutic targets and approaches.
The Starch Food Niche: Human Adaptation, Genes and Culture – Starch4Sapiens
The Starch Food Niche: Human Adaptation, Genes, and Culture
EFFlux pump inhibitors to Overcome antibiotic ResisTance – EFFORT
The EFFORT consortium aims to characterise and develop a novel family of efflux pump inhibitors able to boost the activity of a plethora of antibiotics that are substrates for Gram negative RND pumps. This research program aims to pinpoint the mechanism of action of these novel inhibitors and chemically develop the inhibitors into potent drug like molecules to allow in vivo proof of concept.
Access to perceptual ambiguity: Behavioral, metacognitive, and physiological measures of perception under conditions of uncertainty – AMBISENSE
Access to perceptual ambiguity: behavioral, metacognitive and physiological measures of perception in situations of uncertainty
Exposure to Endocrine Disruptors during early life and child Neurodevelopment: the role of the hypothalamic–pituitary–adrenal axis – EDeN
Child neurodevelopmental disorders usually emerge during childhood, persist into adulthood and are associated with functional impairments. Annual cost of child neurodevelopment disorders has been evaluated at 21€ billion in Europe, making the identification of modifiable risk factors a priority target for public health. In addition to genetic factors known to be important risk factors, exposure to pollutants during critical period for brain development might be involved.
