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Dissecting the molecular mechanism of an antibiotic efflux pump – BIOTIFLUX
Antibiotic resistance is becoming a major threat for human health, and drug efflux pumps contribute to this phenomenon. An increasing number of bacterial ABC transporters, which utilize the energy of ATP hydrolysis to expel drugs, have been implicated in multidrug resistance mechanisms.
Cell wall “clicking” as a selective weapon against Streptococcus pneumoniae – PneumoClick
Faced with the emergence of forms of resistance, the project proposes a new solution to kill only Streptococcus pneumoniae. It is based on the use of the Click reaction and the bacterium ability to metabolise modified metabolites with clickable functions.
Learning to synthesize 3D dynamic human motion – 3DMOVE
It has recently become possible to capture time-varying 3D point clouds at high spatial and temporal resolution, which allows in particular for high-quality acquisitions of human motion. Currently, first tools to process and analyze the data in a robust and automatic way are being developed. Such tools are critical to learning generative models of dynamic human motion. The objective of 3DMOVE is to compute high-quality generative models from a database of dense 3D motion sequences of humans.
Meiotic recombination in plants-controlling the transition of DNA double-strand breaks to genetic crossovers – MEIOREC
The aim of MEIOREC is to decipher the DNA Double Strand Break (DSB) to crossover transitional steps and evaluate strategies to manipulate crossover formation using model species thereby laying the foundation for subsequent translation of the most promising into crops.
Shaping 21st Century AI – SHAPING AI ES-T01069X-1
learning revolution” over 10 formative years (2012 to 2021) in three layers: in the media, in the policy space
Innovative Common Laboratory for Space Spectroscopy – INCLASS
powerful telescope ever launched into space (in 2021). France is strongly engaged in the JWST, particularly
Trillions of gut microbes to rescue AED: the microbiome associated to clinical response in children epilepsy – TrilliAED
Pharmacoresistance to anti-epileptic drugs (AED, ~30 molecules) is a major burden to patients and society, with approximately 25% of the 70 millions worldwide epileptic patients being drug-resistant. Numerous hypotheses explaining resistance to AEDs have been addressed and involve genetic and epigenetic host factors, disease severity, transporters and targets hypothesis etc. Yet part of the resistance may be linked to the metabolism of AEDs by the microbiome.
Multi-redox porous crystalline hybrid chalcogenides – THIOMOFS
Advanced synthesis and characterization of new organic-inorganic chalcogenides, combining porosity, electronic conductivity and multiple redox activity
Engineering antibacterial cationic amphipathic peptidomimetics for targeting biofilm-embedded and intracellular bacteria – AmphiPep
Bio-inspired design of antibacterial agents able to reach sanctuarized bacteria in in biofilm or inside cells - Impact of the shape of amphiphilic architectures on their modes of interaction with membranes and their mechanisms of action.
Plasticity and adaptability to the combined effect of pollution and climate change – POLLUCLIM
Plasticity and adaptability to the combined effect of pollution and climate change
