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Thin-Film coating in AIR with homogenous dielectric barrier discharge – DECAIR
DECAIR aims to demonstrate the scientific and technological feasibility of a roll-to-roll plasma process at atmospheric pressure in air applied to the deposition of a thin and homogeneous layer. To keep the substrate intact and to realize a homogeneous coating on a large-scale surface, we will use a
CrossOver interference phenomenon: regulating crossover number and spatial PATTerning during meiosis – CO-PATT
Homologous recombination is essential to maintain genome stability and to give access to the redundancy of genetic information that exists in the form of sister chromatids or homologous chromosomes when both strands of the DNA double helix are compromised and to generate genetic diversity in differe
Shaping 21st Century AI – SHAPING AI ES-T01069X-1
Talk about “artificial intelligence” (AI) is abundant. Politicians, experts and start-up founders tell us that AI will change how we live, communicate, work and travel tomorrow. Autonomous vehicles, the detection of illnesses, automated filtering of misinformation and hate speech – AI is seemingly s
Mechanisms of intestinal immune response initiation in Peyer's patches – PHAGOMIC
The goal of this project is to obtain a comprehensive overview of microbiota influence on the mucosal immune system through its interaction with Peyer’s patch (PP) phagocytes. We aim to: 1) define the different steps of the intestinal immunity maturation in PP at weaning time, when reshaping of t
HYpoxia and alternatively activated MAcrophaGEs as novel molecular imaging targets for early monitoring of therapy efficacy in Idiopathic Pulmonary Fibrosis – HYMAGE-IPF
There is currently no tool to monitor the progression of fibrosis and the effectiveness of these treatments. The objectives of this project are: 1/ to evaluate the therapeutic efficacy of blocking hypoxia signaling via inhibition of HIF1a, HSP90 and LRP1 in experimental fibrosis, 2/ develop and eva
Control of type A Influenza virus Propagation and Immune Responses: Investigating the role of NCOA7-Alternative Start – CAIPIRINAS
Influenza A virus (IAV) enters the cells via endocytosis and a pH decrease is required for viral and endosomal membranes fusion, and subsequent access of the viral ribonucleoprotein complexes to the cytosol. Endosomal acidification is key to antigen degradation and presentation to immune cells. We h
Innovative strategy to treat Charcot-Marie-Tooth patients based on translational readthrough molecules by in vitro screening using CRISPR-Cas9 and iPSc technologies – NeurIT
Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy in humans (1 in 2500 people). More than 90 CMT genes are known to date. For more than 40% of them, premature stop codon (PTC) mutations are responsible for the disease. These PTC mutations lead to the production of
Engineering antibacterial cationic amphipathic peptidomimetics for targeting biofilm-embedded and intracellular bacteria – AmphiPep
Critical challenges remain in the battle against infectious diseases. The emergence of antimicrobial resistances is not the unique serious threat for patients. Infections associated with bacterial specific lifestyles such as sanctuarization in biofilm or inside cells, are also difficult-to-treat wit
Understanding of the bacterial interaction network within seafood microbiome towards a sustainable biopreservation – SEABIOMIC
Seafood products, and the conditions in which they are stored, encourage the growth of micro-organisms that may originate from fish, seawater or contamination during product processing. As a result, these matrices deteriorate rapidly and are potential vectors for human pathogenic bacteria. Biopreser
ET-Nod : Effectors Triggering Nodulation In legumes – ET-Nod
The main objective of the ET-Nod project was to deepen our understanding of a novel and unconventional symbiotic process involving Bradyrhizobium strains and a wide range of tropical legumes, both cultivated and wild. This process represents a paradigm shift in our understanding of rhizobial symbios
