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Testing the Ménage à Trois Hypothesis – MATHTEST
It was recently proposed that metabolic integration of the plastid into its eukaryotic host required the assistance of third partner, a now extinct chlamydia-like intracellular pathogen. The latter would have left its mark in the form of lateral transfers of genes encoding enzymes in particular metabolic pathways. In the MATHTEST project, we proposed to elucidate this imprint and the evolutionary history of vitamin K metabolism in cyanobacteria and eukaryotic algae.
uORF-mediated post-transcriptional control of stem cell niche activity in plants – ReinitiaTOR
Target of Rapamycin (TOR) functions as a central hub to link a wide range of external stimuli to protein production. In plants, protein production is limited by upstream open reading frames (uORFs) located within the 5’UTRs of about 30% of eukaryotic mRNAs. The mechanism of uORF-mediated suppression of translation and reinitiation factors that mediate uORF inhibitory potential are not yet clear.
Deciphering tolerance breakdown in a human B-cell mediated autoimmune disease – Autoimmuni-B
Which deregulation occurs in human autoimmune diseases and what is the dynamic contribution of each subset of B cells in this process is the central question of this proposal. We will take advantage of a unique model, the antibody-mediated autoimmune disease immune thrombocytopenia (ITP), in which different disease treatments and outcomes delineate distinct pathogenic effector subsets and for which splenectomy allows the study of tolerance breakdown during an immune response in a lymphoid organ.
Dynamic folding and assembly of DNA Origamis: isothermal nanomachines powered by light – DYOR
Dynamic folding and assembly of DNA Origamis: isothermal nanomachines powered by light
Catalysts with Metal-Ligand Cooperation for Sustainable Energy – CatEngy
Catalysts with Metal-Ligand Cooperation for Sustainable Energy (CatEngy) project addresses some challenges of a sustainable chemistry and production of alternative energy source for future generations. Hydrogen and alcohols are potential energy careers. Storage of dihydrogen H2 under safe and easy to handle form is a challenge to overcome for the development of hydrogen-based energies and chemical storage (i.e. dissociated hydrogen) is a topic of intense research receiving strong interest.
At the edges of kinship : origins and new family configurations – ORIGINES
What meaning should be given to the ties uniting people who, without being relatives in the legal sense, are connected by the circumstances of a procreative act? This multidisciplinary project (history, social anthropology, sociology and law) regards the links - real or fantasized - created by the relation to «origins« in the new family configurations (adoption, assisted reproduction, surrogacy).
A MULTIdisciplinary approach to decipher the first step of aroma MIXture perception. – MULTIMIX
Odors that we detect in our environment result from the perception of mixtures of odorants. Several of these mixtures can lead to a homogeneous percept: odor blending or masking by one component.<br />MULTIMIX aims to identify the biological, molecular and sensory characteristics of odorants that contribute to a homogeneous percept. It will provide keys for the improvement of the flavoring of foods formulated according to nutritional recommendations.
New POLlutant EMIssions from modern Euro 6 CarS: atmospheric transformations and implications for urban air quality and health – POLEMICS
The demand for urban mobility is steadily increasing and the growing number of vehicles in cities poses major environmental and health issues. POLEMICS addresses urgent questions on new Euro6 car emissions. The consortium composed by analytical mass spectrometry experts, toxicologists and air quality modellers will investigate the nature, the fate and the impacts on air quality and health (toxicity and genotoxicity) of Euro 6 emissions combining in laboratory and real world measurements.
Low Loading Asymmetric Catalysis with Helical Chiral Oligoureas – HCO_for_LLAC
Urea-Based Foldamers as Hydrogen-Bond Donor Catalysts for Molecular and Macromolecular Reactions
Pseudo-Chiral Resonators for the Optical Detection of Chiral Molecules – ChiROptMol
Photonic resonators have the ability to resonantly interact with light. This resonant interaction allows to increase the coupling between molecules and light and to tune the light properties with resonant scatterers. Achiral nanostructures with optical activity have the great advantage of enhancing opposite circular dichroism depending on the illumination conditions. This unique feature is at the core of the objectives of this work, which is the detection of chiral biological molecules.
