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Endocrine disruptive potential of molecules leaching from food containers. Are substitutes safer? – PoLySafe
Les normes de migration actuelles permettent de vérifier la conformité de la quantité de polymère composant les contenants alimentaires qui passe vers son contenu (60mg de contenant/kg de denrée alimentaire). Aucune norme n’oblige à l’évaluation des effets biologiques des molécules composant les bar
Genetic and Metabolic Determinants of Elevated Lipoprotein (a) – KRINGLE2
The major structural difference between Lp(a) and LDL is that Lp(a) contains a second large protein, apolipoprotein (a) [apo(a)]. Apo(a) is extremely polymorphic in size as it contains 1 to more than 40 kringle-IV2 (KIV2) domains giving origin to more than 40 isoforms in humans. The size of apo(a) i
Towards clinical investigation on the use of Mineralocorticoid Receptor Antagonist for wet Age-Related Macular Degeneration – MR-A-MD
Strategies that aim at extending the duration of anti-VEGF effects (gene therapy, small antibodies, implantable reservoir) will not benefit to all patients because VEGF is not the only molecular target in AMD31. MR-A-AMD aims at validating that MR pathway is a novel and pertinent target to be tested
Death and Grief in COVID-19. Grief and Mental Health of relatives in a restrictive situation of supporting end of life and rites. – COVIDEUIL
From March 2020 onwards, three massive increases in mortality followed by three confinements reduced or even prevented visits to the sick and the deceased in France and throughout the world. In total, 667,400 people died in 2020 who could not be accompanied as they had expressed to their families,
Longitudinal survey on the psychological impact of the COVID-19 pandemic in healthcare workers – PSYCOVER
Background. Healthcare workers directly involved in the diagnosis, treatment and care of patients with Covid-19 during the Covid-19 health crisis were confronted with multiple sources of stress. Studies demonstrate that work overload and stress-related symptoms make healthcare workers particularly v
Impact of Prolonged Nicotine Exposure on the Adolescent and Adult Brain with Relevance for Psychiatric Disorders – NICADO
We have 4 major aims focusing on changes that affect dopamine (DA) neurons of the reward system and their modulation by acetylcholine, the endogenous ligand for nicotinic acetylcholine receptors (nAChRs). 1- To determine how adolescent nicotine exposure shapes VTA DA neuron maturation. 2- To exami
Interrogating vestibulo-cerebellar circuits involved in spatial orientation – InVest
The updating of head direction coding in the forebrain using vestibular signals originating from the inner ear requires their transformation, and in particular the resolution of a number of ambiguities. Our objective is to identify the sub-circuits in the vestibular system which underlie these opera
The French Yellow Vests: A Pluridisciplinary Approach to Popular Politicization and Mobilization – GILETSJAUNES
The objective of this project is to shed light on three complementary research questions using empirical data collected during the first months of the mobilisation and during the project's duration: How do the socio-spatial and sociological characteristics of the GJs show a recomposition of working
Yarrowia lipolytica oleochemicals based on odd chain fatty acids – YaLiOl
The objectives of the YaLiOl project are to: 1) to advance the engineering of Y. lipolytica for the production of odd-chain fatty acids (OCFA); 2) to develop a fermentation medium based on sugar beet molasses; 3) recovering the OCFAs, characterizing them, and transforming them into oleochemical
Natural Breaking WavEs and Sediment Transport during beach recovery – WEST
While offshore transport is strongly linked to current, accretion is linked to wave-generated fluxes occurring in the WBL, generated by steady streaming and wave shape streaming mainly via bedload transport. Previous experiments and numerical studies show that wave boundary layer dynamics are induce
