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Structural and functional studies of import and intermembrane space transfer of mitochondrial membrane proteins – MitoMemProtImp
Mitochondria perform numerous biological functions. they produce all cellular ATP (i.e. energy) and perform key metabolic reactions. 99% of their proteins are produced outside mitochondria and have to be imported. Here, we study key steps of the import of membrane proteins into mitochondria, namely how chaperones and receptors collaborate to achieve efficient targeted import. We combine structural biology and in-vivo techniques to go from the atomic level to the cellular relevance.
Cybergenetic circuits to test composability of gene networks – CyberCircuits
Quantitative and synthetic biology live in a state of quiet denial: while the analogy of genetic to electronic circuits is commonly invoked and depicted, we routinely fail to make correct predictions about network dynamics from “known” properties of the network’s components. We aim to develop novel approaches for understaning and cosntructing synthetic circuits based on hybrid bio-digital citcuits implemented partially in cells and partially in computers.
Capture of the operational Traces of the company’s actors to build human Capital and define the winning Processes – CaTCaP
Learning and evolution of actors' practices, based on individual and collective competencies
Better understanding the evolution of angular momentum in red giants – BEAMING
Measurements of internal rotation in stars at various evolutionary stages have shown that angular momentum is redistributed much more efficicently than predicted by current models. The BEAMING project explores the hypothesis that internal magnetic fields are causing this additional transport of angular momentum in red giant stars.
Chirped Pulse And Resonator In one Spectrometer: A novel combined molecular jet chirped pulse/cavity Fourier Transform MicroWave spectrometer for fast scan, high-resolution, and chiral discrimination – PARIS-FTMW
The chirped Pulse And Resonator In one Spectrometer (PARIS) applies an innovative and resource-efficient approach: Using a smart design, most electronic components are used in a dual-purpose spectrometer while almost all vacuum equipment are shared. Therefore, PARIS is built at much lower costs than two individual spectrometers and exceeds the advantages of both techniques individually: Rapid broadband capabilities, intensity reliability, as well as unrivalled resolving power and sensitivity.
Decoding and monitoring operators’ cognitive states – BLADE
With autonomous vehicles and automated aircraft, humans interact with increasingly autonomous systems. But how can we ensure that these interactions remain safe, efficient, and adapted to human abilities? This project aims to better understand the cognitive states involved in interactions with automated systems, in order to design technologies that enable safer and more optimal interactions.
Role of Type IV pilus retraction in bacterial pathogenesis – RETRACTOPATH
Type IV pili (Tfp) are highly dynamic long filamentous structures that are produced by numerous pathogenic bacteria. They mediate an extraordinary array of functions, including motility, DNA uptake, bacterial aggregation or adherence to host cells. Pilus retraction generates remarkably high force. Such force acts as a mechanical signal to both bacteria and host cells. To date how such force is sensed in host cells and contribute to bacterial pathogenesis has been poorly explored.
Lab-in-Droplet platform for glycoprotein biomarker discovery: from device conception towards diagnostic applications – DropLab
This Lab-in-Droplet will unprecedentedly offer both efficient sample treatment and resolute analytes separation within sub µL droplets. This will be the first platform able to couple sample treatment and analyte separation modules without any problem of working volume mismatch, thus solving the instrumental and methodological bottlenecks currently encountered in analytical module integration.
Structural dynamics of a dimeric GPCR at the single molecule level – DynaMuR2
Our project aims to understand the conformational dynamics of a receptor that is part of the major drug targets.
Robot collaboratif – CoBot
The goal of the CoBot (Collaborative roBot) project is to enable humanoid robots to interact and collaborate safely with humans during handling tasks.<br />The project is in the axe « Interaction, Robotics - Artificial intelligence » of the challenge «Society of information and communication». The project matches gesture, movement, collaborative interactions, increased human, humanoid, adaptable systems, planning, cognitive architecture, autonomous decision, human-robot collaboration, mobility...
