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Impact of the aberrant cell-matrix interaction in Non-Alcoholic fatty liver diseases progression – MATRIXNASH
TASK 1: Decipher the ECM-dependent pathways promoting the development and the progression of NAFLD in different murine models mimicking NAFLD: Focus on a CD44-OPN-HA-TNC signaling axis. By using murine NAFLD models with engineered levels of candidates (e.g. CD44, OPN, TNC), we will determine the rol
A central control hub in DNA damage responses: function and regulation of the RBR module – RHiD
The first aim of this project has been to expand the repertoire of DDR genes in plants. Based on a meta-analysis that successfully pinpointed new DNA damage regulators, which are both transcriptionally upregulated upon DNA stress and identified as target genes of RBR1, an in-depth characterization w
Secure Software using Whitebox Technology – SWITECH
Cryptographic algorithms are increasingly deployed in various applications embedded on connected devices, such as smartphones and tablets. In this environment, the capabilities of the adversary can be greatly enhanced, and we should consider an adversary who can access the binary code, modify its
Dense ARray for seismic site effect Estimation – DARE
The DARE project proposes to exploit data from 2 complementary dense seismic experiments carried out on the Messinian canyon of the Rhône river (South-East France) where some critical infrastructures are located. These data will be used to investigate the contribution and interest of innovative meth
Metamorphism and Properties of Snow from 3D Images: Microscale Experimentation and Simulation for a better Understanding of Involved Mechanisms – MiMESis-3D
The project aims to enable the development of new generation snow models by addressing 6 key points of snow modeling from its 3D microstructure: -Task 1: isothermal metamorphism. The objective here is to develop a digital micro-scale model which describes the evolution of snow in 3D under isothermal
Estimation and control of open quantum systems – Q-COAST
Quantum control attempts to apply and extend the principles already used for classical control systems to the quantum domain. We hope to establish a control theory specifically dedicated to the regulation of quantum systems. This proposal addresses some key issues related to the control of open qua
Computational analysis of the response of immune repertoires to viruses – RESP-REP
The immune system relies on its diverse repertoire of specific B- and T-cell receptors (BCR and TCR) to recognize the large diversity of pathogen-derived antigens. The composition of the BCR and TCR repertoires carries the footprint of past immune responses and is informative about the ability to fi
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
As a consequence of their rigid three-dimensional structure, deck-substituted [2.2]paracyclophanes (pCps) can exhibit planar chirality and are nowadays considered as promising building blocks in organic synthesis. Nevertheless, the preparation of enantiopure poly-substituted paracyclophanes is often
Cell wall “clicking” as a selective weapon against Streptococcus pneumoniae – PneumoClick
Creating chemical bonds in a controlled manner in a living cell has a great potential of applications in the fields of biology and medicine but remains a major challenge. In the PneumoClick project, we will exploit click chemistry and specificities of the cell wall biosynthesis pathway in the human
Towards exoskeleton-human symbiosis: investigating how humans interact with an upper-limb robotic exoskeleton – EXOMAN
The overall objective of the EXOMAN project is to improve the symbiosis between humans and exoskeletons. To do so, we plan to produce new fundamental knowledge on Human-Exoskeleton Interaction (HEI) by focusing on the human dimension. The use of exoskeletons is promising in the fields of ergonomics
