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In vivo gynogenesis in maize: novel insights into plant double fertilization – NOT-LIKE-DAD
A deviation from the classical double fertilization process of higher plants induces in peculiar maize lines haploid embryos containing only the maternal genome. This project aims to use this unique maize line as tool to better understand plant sexual reproduction.
Individual muscle Coordination strategies and their role in the development of musculoskeletal disorders – COMMODE
Our primary testable hypothesis is that each individual has unique muscle coordination strategies that will have specific mechanical effects on his/her MSK system. As such, some strategies would make people more at risk of developing MSK disorders than others.
Structure and function of endogenous TFIID-containing complexes – PICen
TATA-box Binding protein (TBP) is delivered to gene promoters by either TFIID or SAGA complex. These complexes not only nucleate PIC formation, but have been suggested to function also as a transcriptional co-activators by interacting with transcription activators. Importantly, the structure of native PICs is not known, leaving open the possibility that the composition and architecture of in vivo assembled PICs may differ from that reconstituted in vitro.
Role of the amygdala-prefrontal network in the emergence of anxiety across childhood and adolescence: Impact of early life adversity in a nonhuman primate model – Anxiomonk
Adverse childhood experiences are strongly linked to psychiatric vulnerability, yet mechanisms remain unclear. Rodent studies highlight limbic plasticity, but translation to humans is limited. Anxiomonk addresses this gap by providing the first longitudinal evidence in nonhuman primates, bridging ethology and neuroimaging to uncover how early adversity alters socio-emotional and neural development.
Toward Non-Invasive Ultrasound Surgery – TONUS
Only 25% of patients with primary or secondary liver tumors are candidates for curative treatment. Focused ultrasound has the potential to be a new therapeutic option but major innovations are needed. The challenge of the TONUS project is to implement these breakthrough innovations and to demonstrate the feasibility, efficacy and preclinical safety of this new treatment in order to be able to start using it in clinically.
Impacts of Microclimatic Processes on foRest bIodiversity redistributioN under macroclimaTe warming – IMPRINT
Impacts of Microclimatic Processes on foRest bIodiversity redistributioN under macroclimaTe warming – IMPRINT
A-site Manganites for mAgNetoelectrics and mulTiferroics from extreme conditionS – AMANTS
The hypotheses underpinning this AMANTS project are 1) that a variety of novel A-site based Mn oxide perovskites and related phases can be recovered from high pressure synthesis, and that these new materials will have interesting and potentially useful properties. And 2) that the new playground of “hard-soft” synthesis has an important role on the new A-site Mn2+ materials by modifying their anion lattices.
Deciphering the Cell Senescence Code to Improve Healthspan – S-ENCODE
Senescence is a cellular response to nonlethal genotoxic and oncogenic stress Cellular senescence is a double-edged sword process playing beneficial roles during embryogenesis, wound healing, and tumor suppression while contributing to age-related diseases. Consistently, senescent cells are enriched in the affected tissues of these diseases. Importantly, senescent cell elimination in animals prevents the appearance of age-related diseases.
Target Ion Source for Short-Lived Ion Production – TULIP
The study of exotic nuclei is one of the main avenues of research with a high potential for discoveries worldwide. The TULIP project aims to enhance near-term nuclear physics research possibilities by creating unique radioactive ion beams (RIB) for ambitious subatomic experiments at the national flagship facility SPIRAL based at the Grand Accélérateur National d’Ions Lourds (GANIL) in Caen.
