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New selective Inhibitors for deciphering Lipid metabolism and virulence in M. tb – LipInTB
Tuberculosis (TB) caused by the pathogenic bacterium Mycobacterium tuberculosis (M.tb), is the deadliest infectious disease worldwide. Treating TB takes a minimum of 6-9 months. The emergence of drug resistant strains amplifies the incidences of TB, mainly resulting in failure of treatment and death. There is thus an urgent need for novel therapeutic targets and approaches.
Genome-wide mapping of G4-ligand binding sites at single-base resolution – NEMESES
Development of chemical biology tools to unlock G-quadruplex DNA secondary structure functions in DNA biology. This project aims to finally unveil G-quadruplex formation and accessibility during the different phases of the cell cycle and their role in regulating replication, transcription, translation, and DNA repair.
Genetic landscape of cardiomyopathies – Landscardio
Cardiomyopathies are an important worldwide public health problem. Available therapies are insufficient. Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a neglected disease affecting around 8 million people, with no effective antiparasitic drugs or vaccines. Assessment of rare variants with whole exome sequencing (WES) has disclosed rare heterozygous pathogenic variants in mitochondrial and inflammatory genes associated to CCC cases.
Exhaust gas selective sensing using printed RF gas sensors – CARDIF
Exposure to toxic gases or volatile organic compounds affects public safety and health. With the Internet of Things, widescale roll-out of gas sensors becomes accessible in order to monitor and analyze the environment, in public or private spaces. CARDIF project aims for the development of devices printed on flexible substrates and based on transduction in the radiofrequency range.
Testing the evolutionary species interactions - abiotic stress hypothesis – E-SIASH
Why do we observe species occurring in certain habitats but not in others? Since the days of Darwin researchers debate this fundamental question and the relative role of environment versus species’ interactions in driving species distribution patterns. While central to basic and applied research associated hypotheses 1) lack the integration of contemporary evolution and 2) remain largely untested empirically.
Rainfall Wind Turbine or Turbulence – RW-Turb
RW-Turb relies on the expertise of HM&Co in measurement and modelling across wide range of spatio-temporal scales of atmospheric turbulence and rainfall to quantify the impact of the latter on wind power production. <br />This project benefits from an industrial partnership with Boralex, a wind power producer.<br />RW-Turb will open new paths to improve nowcasts of power production, a major challenge in a framework of increasing use of renewable energies in France and Europe.
Light Induced CO2 2-Electron Activation and Mechanistic Insights – LOCO
Scientists are urged to produce sustainable energy vectors based on the solar conversion of CO2 to energy-rich synthons. We have witnessed a prolific number of new electro- and photo-catalysts for the reduction of CO2. However, we are far from having in hands solutions to deploy on a large scale. Understanding photophysical events in multi-electron catalysis is of primordial importance and stand as the bottleneck in the optimization process for efficient photochemical reduction of CO2.
Integrating microbial METAbolism into CLOUD chemistry: from" omics" to a model – METACLOUD
METACLOUD is focused on studying the ability of the cloud microbiome to metabolize single carbon (C1) compounds and integrate it into a model of atmospheric chemistry. Its originality is «omic« methods. For the moment these biological processes are not described in the models.
Self-organized multifunctional multi-material structures for LED lighting – SMARtLEDS
In LED devices, many photons emitted by the source are not part of the final produced light due to internal reflective effects which trap them inside the luminescent coating associate to the device. These effects can be reduced through the surface patterning of coatings. The classical patterning methods offer great performances but are expensive and not suited for a large-scale use. This is why this project aims to develop ZnO/phosphor composite structures as a low cost and green alternative.
Ring opening co-polymerization of succinic anhydride derivatives and epoxides from bio-based resources via organocatalysis – CoCaBio
Considering the environnemental impact and the futur shortage of fossil ressources, the development of materials originated from renewable ressources has become a global concern. The main purpose of this project is to place organocatalysis in the service of ring opening polymerization, for the synthesis of polymers based on renewable resources.
