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New approaches to bridge the gap between genome-scale metabolic networks and untargeted metabolomics – MetClassNet
1. Develop a novel computational framework to build multilayer networks integrating different knowledge-based networks and experimental networks. 2. Develop state of art computational solutions exploiting the multilayer topology to improve the power of metabolism analysis such as gap filling, metab
UPscaling and heat simulations for improving the efficiency of deep GEOthermal energy – UPGEO
Geothermal energy, namely the mobilization of the subsurface heat at very low, low or high temperatures, is one of the methods to achieve the energy transition. There is a real risk that an installation may not reach a geothermal resource with sufficient flow and temperature characteristics to ensur
Integrative study of cogNitive abilities on Social InTeractionS in Drosophila melanogaster – INSIghTS
INSIghTS aims to obtain a multi-level understanding of the fundamental mechanisms underlying social behaviors, winner/loser effects and chemosensory perception, with three objectives: OBJ1. Characterize brain neural circuits required for formation, maintenance and recall of winner/loser effects. We
Deciphering the mechanisms involved in the hyperaccumulation of alkaline earth metals by cyanobacteria – HARLEY
A first objective aims at identifying the structure and the function of a protein, named calcyanin, which is unknown until now but whose presence is correlated among cyanobacteria with their capability to form intracellular carbonates. A second objective aims at developing the genetics approaches i
Adaptation mechanisms in food-fermenting Penicillium fungi – FUNGADAPT
Studying adaptive divergence, a key process in evolutionary biology, is essential for understanding the adaptation of organisms to their environment and how biodiversity arises. Domestication is a good model for studying adaptive divergence, as it involves strong and recent selection for known trait
Genetic and epigenetic regulation of life cycle progression in the model brown alga Ectocarpus – Epicycle
The objective of the Epicycle project was to elucidate the genetic and epigenetic processes associated with life cycle progression and the deployment of the sporophyte developmental program in the multicellular model brown alga Ectocarpus. The project combined detailed molecular characterisation of
Simulation and Imaging for Mitral Regurgitation – SIMR
This project aims to contribute to this major public health problem with the following two objectives: (i) Evaluate the impact of preoperative fibrosis on left ventricular remodeling after mitral repair surgery in a clinical study involving 15 patients. (ii) Develop numerical tools for the simulatio
Self-assembled printable hydrogels from biocompatible amphiphiles for tissue engineering – SELFAMPHI
1. The mechanical properties of hydrogels can be adjusted. Microbial glycolipids are known to self-assemble in a wide variety of structures, some of which can form hydrogels at concentrations as low as 1% by weight. It is crucial to control the nanoscale and macroscopic structures of self-assembled
IoniC LIquid Crystals: Towards TunAble-by-Design ElectroLytes – CITADEL
The basic research-oriented core novelty of CITADEL lies in the direct comparison of two types of soft-matter based advanced electrolytes: i) dynamically self-assembled monodomains of Anion/Cation-conducting Thermotropic Ionic Liquid Crystals (A- vs. C-TILCs) enabled through the application of an ac
Domestication as a step towards reproductive isolation – DomIsol
Climate change is the biggest challenge that we are facing for food production. Increase in atmospheric carbon dioxide, in temperature and in variability of precipitation, directly affect the abiotic environment of crops, their geographical distribution and their biotic interactions, leading to incr
