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Single Nanopore for Analysis of Early Stages of ß-Amyloid Aggregation Leading to Alzheimer’s disease – NANOoligo
Developing tools for amyloid fibrils analysis at early stage able to discriminate the different population of oligomers and protofibrils and to evaluate the impact of promoters or inhibitors through amyloid shape analysis is particularly important to understand the external factor on Alzheimer disease. Our project aims at proposing a new analytical method based on nanopore technology to study the Aß42 amyloid fibril growth.
Extremal Regression with Applications to Econometrics, Environment and Finance – ExtremReg
First, the investigation of mathematical properties under frontier models is often a lot harder than under the standard regression models. Second, while the extreme value properties of quantiles are well developed, much less is known about their expectile and extremile analogues. Third, the problem of estimating conditional extremes and risk measures in high dimensions has been much less discussed in the literature. Our project tries to solve <br />these issues in different directions.
Optical coherence tomography for REtinal Organoid imaging – OREO
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases that result in selective cell death of photoreceptors. <br />Human induced pluripotent stem (iPS) cell technology generates retinal organoids for disease modeling purposes, and cell-based rescue or replacement strategies. <br />High resolution imaging tools are essential to perform to monitor bioproduction of these cell cultures and to validate disease models and therapeutic solutions.
ARCHI-SEC: Micro-Architectural Security – ARCHI-SEC
Security Analysis at Micro-Architectural level
SImulations with high-order schemes of tranSport and TurbulencE in a tokaMak – SISTEM
Simulations with high-order schemes of tranSport and TurbulencE in tokaMak
Fundamental, genetic and clinical aspects of male infertility due to severe sperm flagellar abnormalities – FLAGEL-OME
Although multifactorial, male infertility has a strong genetic basis, which has so far not been extensively studied. Previous work permitted to characterize and publish causative mutations in 9 genes. Here, the same consortium will leverage the previously acquired expertise and tools to further investigate the molecular basis of flagellogenesis and to translate this knowledge into actionable information and strategies to improve diagnosis and care of infertile patients.
Dislocations and Resistances. Persecutions and Genocidal Violences of Roma, Sinti and Travellers in Western Europe, 1940-1946. – ROMARESIST
This project studies, following a comparative and transversal approach, the persecutions against the Roma and Sinti, designated as “Gypsies”, “Zigeuner”, “Zingari” or “Nomads” in the geographical arc including the Netherlands, Belgium, France, Italy and Occupied Slovenia. The cross-analysis of the stages and mechanisms of a persecution includes a study of the trajectories at the level of individuals and collectives, based on a survey that is both historical and ethnographic.
Innovative Chiral Molecules for the Construction of Efficient Circularly Polarized Light Emitting Devices – iChiralight
The development of Circularly Polarized Organic Light Emitting Diodes (CP-OLED) based on chiral emitter has received renewed attention as a potential direction for increasing the energy efficiency and the contrast of conventional OLED displays. However, combining both high electroluminescence circular polarization and device performances has never been done so far and remains a considerable challenge for potential optoelectronic applications.
Remote functionalization of molecules with supramolecular catalysis – REMOTCAT
The functionalization of C-H bonds constitutes an important research direction because these bonds are abundant and it is possible to achieve molecular complexity by reducing costs and waste. However, the objective of achieving a particular selectivity in the presence of several C-H bonds is a major challenge because the associated energy to distinguish these bonds is very similar, as is the case for pyridines, molecules sought by pharmaceuticals.
Structure and molecular function of the pseudopilus in type 2 protein secretion pathway – SYNERGY_T2SS
Synergy_T2SS aims to decipher the structure and function or the pseudopilus - the dynamic motor of type II secretion system, and that in three model bacteria.The current models of the secretion mechanism - «piston« and «archimedes' screw« predict different pseudopilus dynamics and interactions with the secreted substrates. We aim to test these prediction using integrative approaches, and to propose a unified and experimentally validated model of type II secretion mechanism.
