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Overcoming the limitations of existing ion channel high-throughput screening and analysis methods by using Bioluminescence Resonance Energy Transfer – CANALBRET
Our consortium hypothesizes that the advent of well-designed intra- and intermolecular Bioluminescence Resonance Energy Transfer (BRET) probes targeting ion channels will provoke a paradigm shift in the field of ion channel biology.
Dissecting the molecular mechanism of an antibiotic efflux pump – BIOTIFLUX
Antibiotic resistance is becoming a major threat for human health, and drug efflux pumps contribute to this phenomenon. An increasing number of bacterial ABC transporters, which utilize the energy of ATP hydrolysis to expel drugs, have been implicated in multidrug resistance mechanisms.
Structural Mass Spectrometry to study the interplay between proteasome complexes regulation mechanisms – ProteasoRegMS
The proteasome is an essential multi-enzymatic complex responsible for the correct recycling of proteins that could be deleterious to the cell. Its proteolytic activity is thus tightly regulated by different mechanisms. In this project we aim at better understanding the interplay between these mechanisms, using innovative Mass Spectrometry approaches and in the context of Irritable Bowel Diseases.
Discontinuities and Vector-Borne Diseases in Urban Areas. A Simulation Model of a Complex Pathogenic System. – MO3
Discontinuities and Vector-Borne Diseases in Urban Areas. A Simulation Model of a Complex Pathogenic System.
Microscale modeling of fracture-matrix interactions under reactive two-phase flow – FraMatI
Microscale modeling of fracture- matrix interactions under reactive two- phase flow
Nano-mechanical engineering of 2D materials – CHACAL
The objective of the CHACAL research program is to better understand the behaviour and mechanical stability of 2D materials under local mechanical stresses, with a particular focus on their response/resistance to buckling under compressive stresses.<br />Our experimental approach consists in synthesizing/characterizing graphene on substrates of interest, and then thermo-mechanically stressing them.
Agglomerated powders for thick ceramic coatings by solid-state dynamic spraying – CERASOL
The aim of the CERASOL project (ANR-19-CE08-0009) is to develop ceramic powders adapted to cold gas dynamic spraying known as “cold spray” process.
Carbo-silylation Reactions as Central Tool for the Synthesis of Complex Silaheterocycles – C-Sil
Silicon-containing heterocycles are very valuable scaffolds as they have shown specific properties in very different fields such as, but not limited to, materials, fragrances and pharmaceuticals. Due to the lack of synthetic methodologies for these compounds, there is an urgent need to develop simple and environmentally friendly approaches.
Thermomorphic Polyethylene-Supported Organocatalysts for the Valorization of Biomass and CO2 – ThermoPESO
Valorizing biomass and CO2 represents great challenges and implies the development of new catalytic tools. In this context, the thermoPESO project proposes to develop organocatalysts supported on innovative polymeric supports, that facilitates their recoverability and their recycling without compromising the catalytic activity.
Impact of climate change on forest reproduction and regeneration – FOREPRO
Providing robust projections of forest dynamics in the future requires predicting how climate change and societal decisions will affect not only fruiting dynamics (masting), but also the demography of seed-consumers and their effect on forest regeneration.
