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Morphogenesis, organization and functions of liquid viral factories formed by Mononegavirales – LiquidFact
Infection of the cell with the rabies and measles virus induces the formation of viral factories (VF) that house the synthesis of viral RNAs. VFs are liquid organelles formed by phase separation. We want to characterize the composition and organization of UVs; identify the molecular bases behind the phase separation; explore the link between UV, innate immunity and the cellular translation machinery; and understand how virions leave the UV.
pH Observation of Extracellular Fluid by NMR Involving Xenon – PHOENIX
The goal of the PHOENIX project is to develop a sensitive, specific and non-invasive method to assess and monitor extracellular pH in vivo. This concept is based on the design of pH sensors that can bind 129Xe at physiological pH. Thanks to the high sensitivity of the hyperpolarized 129Xe NMR/MRI technique, this approach will represent a fast and easy way to detect pH variation in tissues and has many advantages over the existing techniques aimed at measuring extra-cellular pH.
Innovative formulations based on deep eutectic solvents for the treatment of cutaneous leishmaniasis. – ParasiDES
The objective of the ParasiDES project is to develop a new topical treatment of cutaneous leishmaniasis that is simple, effective and inexpensive.
IntEgrated verticAl Modulator onto VCSEL for ultra high speed optical interconnects – EAM-VCSEL
The goal of the EAM-VCSEL project is to develop a cost- and energy-effective laser-source technology for short range Tb/s optical data communication links by extending the high-speed capability of VCSELs to beyond what is possible using direct current modulation.
Search engine for environmental genomic sequencing data – SeqDigger
New scaling breakthrough, allowing users to directly query large unassembled raw sequencing data on the fly in order to tap into the largest underexploited resource in life sciences.
The environment and human health across life and social sciences – ENVIROBIOSOC
The EnviroBioSoc project aims at determining whether or not it is actually possible and suitable to overcome the state of plurality characterzing the study of environnementally induced diseases by looking for an integrative and interdisciplinary approach to the environment. This approach would combine the various ways the environment is conceived and operationalized in health studies, both in life and social sciences.
Ecological Fitness of Light Color Acclimation in Marine Cyanobacteria: a Cross-Scale Analysis – EFFICACY
Global change is predicted to have numerous consequences on ocean properties and notably on ‘ocean color’, used by modelers to assess chlorophyll biomass at global scales. For phytoplankton cells, changes in ocean color are perceived as a modification of their light niche and trigger competition between species, resulting in dramatic changes in community composition. The EFFICACY project therefore tackles the question of the respective fitness of phytoplankton species to adapt to these changes.
Evolution of chemoreception in relation to land-to-water transition(s) in Adephaga beetles – Evo-AquaSense
Chemical senses play a key role in species adaptation to new ecological niches, notably in insects. Understanding how the fundamentally aerial chemosensory equipment of insects was remodelled in lineages that underwent land-to-freshwater transition is of major interest to evolutionary ecology but remains unexplored.
Surface and volume modulation of fast deforming cells and organelles – SurVol
Cells are often described as almost spherical objects. However, the dense environment of the tissues keeps them away from this simple shape. Cells can undergo rapid deformation as they migrate through dense tissue and as they move through blood capillaries. In this project, we propose to study the large deformations of cells, the associated responses and their importance for the migration of immune cells.
Peptidergic control of pain and emotions: relaxin-3/RXFP3 modulation of descending pathways – RELAX
La douleur chronique est un problème de santé publique avec d’importantes conséquences économiques. La douleur et l’anxiété ou la dépression sont les symptômes les plus fréquents en consultation et sont souvent associés. Malgré leur prévalence, les syndromes douloureux chroniques et leurs comorbidités demeurent un enjeu clinique mal maîtrisé.
