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Unrevealing the neuronal circuits underlying chronic pain – PaiNetWork
The goal of the PaiNetWork project is to characterize the phenotype, the function, and the synaptic connectivity of the neural microcircuits underlying mechanical allodynia at the peripheral, segmental, and supra segmental levels, under neuropathic or inflammatory conditions. Behavioral results meas
Role of intracellular trafficking in the control of Immunoglobulin Receptor-mediated diseases – IDEA
The mechanisms by which IRAP controls FcR activation and how these impacts diseases are unknown and will be investigated by the 4 working packages of the IDEA project: WP1. Understand the molecular mechanisms by which IRAP facilitates FcgR activation : This WP will include cellular biology method
Polycomb Repressive Complex in Paramecium: interaction with small RNA machinery and substrate specificity – POLYCHROME
In Paramecium, newly established chromatin regions with Polycomb signatures are removed from the somatic genome during development of the somatic nucleus (MAC). All transposable elements (TEs), as well as 45,000 degenerate, single-copy remnants of ancient TE insertions (IESs) are eliminated from th
Regulation of ribosome activity by rRNA 2'-O-methylation: Toward rRNA epitranscriptomic control of translation – ActiMeth
Deciphering the mechanisms of protein synthesis regulation is crucial in our understanding of gene expression in both healthy and pathological tissues. Historically, the genetic sequences present in messenger RNAs (mRNAs) and proteins that bind to mRNAs were considered to be the sole regulators of p
The microbiome-gut-brain axis in Autism Spectrum Disorder – MICROBIAUTISM
Microbioautism have the following aims: 1) Determine in mice the impact of fecal supernatant of ASD patients (FS-ASD) on gut and brain functions and associated cellular and molecular changes. 2) Identify the role of the secondary bile acids, desoxycholic acid (DCA), as a putative candidate in gut an
Space-based Observations of the ice Sheets: Ice mass changes evaluated from 2013 to present. – SOSIce
The advent of spaceborne remote sensing first allowed the collection of large amounts of data over remote and isolated places such as the ice-sheets. For the first time, continent-wide mappings have enabled a more precise description of the dynamical and geometrical structure of the ice-sheets and h
Ruling on Nature. Animals and the Environment before the Court – RULNAT
The animal and nature protection debate has intensified across the world, and animal welfare and ecological issues are repeatedly brought before courts. These issues are now considered a complex and delicate matter involving animals’ or nature’s own interests, particularly (with regards to animals)
Confined Lewis Acid/Base – Co-LAB
The objective of this project is (i) to activate small gas molecules and (ii) to perform multiple catalysis (double cooperative catalysis, relay catalysis), using different catalytic sites isolated thanks to their endohedral confinement in covalent cages. New cages with a confined Lewis base could b
Strong and Tunable Zinc(II) Cationic Lewis acids: synthesis and use in selective Catalysis – Tu-Zin-Cat
The fundamental reactivity of Zinc cations will be studied and exploited for catalytic reactions of current interest, including their use for the selective transformation of biomass substrates (carbohydrates and sorbitol) to added value products and for the hydro-elementation (hydro-boration/-silati
Plankton: biological pump of contaminants in marine ecosystems (CONTAMPUMP)? – CONTAMPUMP
The CONTAMPUMP project aims to understand the biological mechanisms of metallic and organic chemical contamination at the base of marine food webs in pelagic and benthic plankton and plankton consumers. The objectives of the CONTAMPUMP project are to answer the following questions: (I) does the siz
