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Sphingosine-1-phosphate Signaling in the Peripheral Vasculature. – SphiPerVasc
The objective of this project is to define how sphingosine 1-phosphate (S1P) signaling is elicited to regulate resistance artery function and assess if deregulated S1P production contributes to the development of hypertension. To this end we will evaluate vascular function, tissue perfusion, blood pressure, and organ injury in the context of temporal or spatial deficiency in S1P production or S1P receptor (S1PR) expression in mice.
Trillions of gut microbes to rescue AED: the microbiome associated to clinical response in children epilepsy – TrilliAED
Pharmacoresistance to anti-epileptic drugs (AED, ~30 molecules) is a major burden to patients and society, with approximately 25% of the 70 millions worldwide epileptic patients being drug-resistant. Numerous hypotheses explaining resistance to AEDs have been addressed and involve genetic and epigenetic host factors, disease severity, transporters and targets hypothesis etc. Yet part of the resistance may be linked to the metabolism of AEDs by the microbiome.
Global Enamels: A Symmetrical History of Cultural and Technological Exchanges Between France and China (mid-17th to end 18th Century) – EnamelFC
Global Enamels: A Symmetrical History of Material and Technological Exchanges<br />Between France and China (mid-17th to end-18th Century)
Biomechanical cost quantification for wheelchair accessible cities – CapaCITIES
Locomotion with a manual wheelchair overloads the upper-limbs of the manual wheelchair users to an important stress, which varies according to the environment. To assist users in selecting the paths that preserve their upper limbs, a cost reflecting the physical demand to which the user is submitted according to the possible paths must be attributed and compared to manual wheelchair users' individual capacities.
Mechanical Energy Storage and Absorption in Microporous Materials by High-Pressure Intrusion of Electrolyte Solutions – MESAMM
Mechanical Energy Storage and Absorption in Microporous Materials by High-Pressure Intrusion of Electrolyte Solutions
Inverse modelling of BLACK Carbon emissions using real time data from NETworked sensors – BLACKNET
Black carbon is a tracer of any combustion and therefore of any human activity or natural event that consumes carbon energy. In South-East Asia, there are many such activities and events. It is important to be able to monitor changes in the intensity and location of these sources in order to report on the transition underway and its effects on the environment and climate.
Realistic modelling for Earth's magnetic field reversals – revEarth
The reversals of the Earth's magnetic field remain mysterious in more than one way. The underlying mechanism is unknown.<br />Using more realistic numerical simulations, innovative numerical methods, and advanced theoretical approaches, we hope to lift the veil on this intriguing phenomenon.
Topological IV-VI semiconductor heterostructures: A platform to study topological phase transitions and strain sensitive topology – TOPO-PLATFORM
The central objective of this project is to resolve the technological challenges for the realization of topological heterostructures and answer the question of how the topological interface states can be tuned and controlled by external means.
Redox regulation of plant HDAC activity in response to climate change – REPHARE
Whether and how histone deacetylase activity is regulated by redox during plant response to high temperature
