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Ultrafast Reactivity of Biomolecules under Irradiation – RUBI
The main objectives of RUBI are twofold. One is methodological, the other one is applicative. On the methodological side, the objective is to develop an hybrid scheme cpupling DFTB and MMpol in the software deMon-Nano, The other one is a transition scheme between BOMD and Ehrenfest MD in deMn2k. -
Multimodal imaging combining Raman and mass spectrometry applied to tuberculosis – MultiRaMaS
On the one hand, as an emerging and challenging strategy multimodal imaging combining Raman Scattering (RS) and Matrix-Assisted Laser Desorption/Ionization (MALDI) MSI needs further improvements: 1) optimization of a stringent and common sample preparation including cryo-sectioning and accurate iden
Innovative analytical methodologies for biotherapeutics analysis in biological samples – MethAmAbs
Monoclonal antibodies (mAbs) are enjoying significant success as a therapeutic agent. This advantage is explained in particular by a favorable half-life as well as the possibility of specifically targeting the associated antigen. Due to their recent introduction as a therapeutic agent, the evolution
Dual Feedback Streams and Laminar integration of Long-range Inter-areal Processes in Primate Cortex – Dual_Streams
The Knoblauch team published a highly influential article on the anatomy of hierarchy (Markov et al., 2014) that laid down the empirical data supporting two important concepts: the Hierarchical Distance Rule and the Dual Counterstream Architecture (DCA). Pascal Fries’s team reformulated the Hierarch
Targeting Glutamine Metabolism to prevent Diabetic Cardiovascular Complications – GlutaDiab
We hypothesize that targeting glutamine-dependent pathways in monocytes/macrophages may limit the inflammatory phenotype and CV events in diabetes. We will test this hypothesis using the combination of unique human studies, mouse models and genome-wide molecular and epigenomic analyses to dissect t
Multimedia archives enhancement: multimodal machine comprehension of language for new intelligent interfaces of scientific and cultural mediation – ARCHIVAL
Digital technology transforms the way people access knowledge, which remain difficult to reach despite numerous attempts to index and structure texts, videos and images according to structured repositories. Often presented as functional lists, search results interfaces offer few navigation and explo
Collective excitations in topological matter – Colector
Collective excitations in topological matter represent a novel field of research focusing on joint effects of non-trivial topology of energy bands and electron-electron interactions. To date, there is little experimental work dealing with Dirac plasmons at the surface of topological insulators, and
Conformational design for high throughput MS/MS reading of digital polymers – shapeNread
The general scientific context of the shapeNread project is massive and long-term data storage, with the need for alternative media to hard disks that are currently employed and require energy-consuming data centers to store quintillion bytes of data generated every day. A key issue is to increase s
Integration of spinal sensorimotor information in the cerebellar cortex during locomotion – SpinoCereLoco
The initial objectives of this project were to recruit a postdoc to the project, build a new two-photon microscope, implement the fictive locomotion preparation underneath the microscope, and begin to image populations of identified cells in the cerebellar cortex. This initial phase would involve st
Proof of concept for the functionalization of lignins by applying laccase-dehydrogenase enzymatic treatments in biobased materials applications – FuncLIPRO
The objective of the project is to bring the proof of concept of the use of laccases to transform under-valued by-products, i.e. lignins generated by the pulp and paper industries, into green adhesives, protective coating films and new agro-sourced composites. Scientific objectives: understanding
