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Aeroclipper Cyclone Intensity Observation – MICA
system by conducting a test campaigns in 2020 and in 2021 with a new mechanical system and a new gondola currently
Role of cAMP signalosomes in cardiomyocyte senescence and age-associated heart failure – SIGNALAGE
The increase in longevity is associated with a wider prevalence of heart failure with preserved ejection fraction (HFpEF). While the incidence of HFpEF in terms of mortality is constantly growing, treatments remain unsuccessful because of insufficient knowledge on the mechanisms of cardiac ageing. In an original approach, our consortium proposes to develop and share appropriate models to better understand HF in the context of ageing.
High-temperature & high-polarization cuprate multiferroics – HTHPCM
Magnetoelectric multiferroics which combine electric and magnetic dipole orders, are multifunctional materials with high potential in new technologies. It can be used to reduce computer memory energy consumption, to improve magnetic field sensors or in spintronic applications. Unfortunately, too few ME crystals are known to date, and even less could lead to industrial applications. Indeed, they usually give a small response and need low functioning temperature to exhibit the desired properties.
Regulatory networks governing craniofacial muscle diversity – MyoHead
Craniofacial malformations are among the most common human birth defects and have multiple etiologies that affect diverse tissues. The underlying genetic, developmental and clinical causes of these malformations are largely unknown. Therefore we aim to identify all of the cell types that give rise to craniofacial structures and the molecular regulators that lead to the establishment and morphogenesis of the various cell lineages in the head.
Looking for proteins regulating Peptidoglycan synthases – LookingForPegase
The characterization of the mode of action of the PBP regulators studied in this project will contribute to a better understanding of the inner-workings of bacterial cell morphogenesis. In applied terms, it will open new avenues towards the rational design of new antibacterial drugs and new strategies to combat bacterial infections, notably antibiotic resistant-strains.
Unrevealing the neuronal circuits underlying chronic pain – PaiNetWork
This project tests the hypothesis that chronic pain is mediated by different neuronal circuits in the spinal cord dorsal horn, depending on pain etiology.
Role of intracellular trafficking in the control of Immunoglobulin Receptor-mediated diseases – IDEA
Internalization of receptor-ligand complexes can either terminate or amplify and sustain receptor signaling. However, the role of endocytosis in the signaling of FcR have never been investigated. The hypothesis of the IDEA project, which is supported by our preliminary data, lift “the scientific barrier” of exclusive signaling of FcR from the plasma membrane.
Polycomb Repressive Complex in Paramecium: interaction with small RNA machinery and substrate specificity – POLYCHROME
Polycomb Repressive Complex 2 (PRC2) trimethylates histone H3 on lysine 27 (H3K27me3), catalyzed by the Enhancer-of-zeste lysine methyltransferase subunit. Despite intensive research, the mechanisms that regulate the activity of the Polycomb complex and control its targeting remain largely enigmatic and are the focus of our research program POLYCHROME.
Regulation of ribosome activity by rRNA 2'-O-methylation: Toward rRNA epitranscriptomic control of translation – ActiMeth
Decipher the variable elements of the ribosome contributing to regulation of translation.
The microbiome-gut-brain axis in Autism Spectrum Disorder – MICROBIAUTISM
The pathophysiological role of the gut microbiota in ASD and the mechanisms underlying microbiota-induced gut-brain axis dysfunctions remain unknown. To lift this scientific barrier, we hypothesize in the Microbioautism project that gut dysbiosis in patients with ASD results in an abnormal composition of metabolites contributing to altered gut and brain functions.
