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GET OP STAND OP : crossing Geochemistry, Exposure, healTh: Oxidative Potential, a first STANDardization before OPerativeness. – GET_OP_STAND_OP
Determination of the reliability of the oxidative potential as a relevant indicator of fine-particle-related health effects, a necessary step before its evaluation as a new metric for air quality regulation.
Social Uses of War Ruins: Resilience, Commemorations and Heritage – RUINES
The purpose of the RUINES project is to analyse the evolution of political and social uses of wae ruines from 16th c. to the present day, as vehicles and symptoms of a systematic historical view characterised by the conversion of warlike events as tokens of a contemporary world that is essentially catastrophic and traumatic.. The central hypothesis is that the way in which societies relate to the vestiges of war says something about how they relate to the past.
Astronomical solution for the Mesozoic Era – AstroMeso
The AstroMeso project aims to go beyond the horizon of predictability of 60 Ma for the Solar System, and to provide the basis of an astronomical solution over the whole Mesozoic. This will only be possible by using the geological record as an input, in order to constrain the orbital solution. This will open a new era where the geological record will actually be used to retrieve the orbital evolution of the solar system.
Interdependent Dynamics of EArthquake-prone fault Systems – IDEAS
Interdependent Dynamics of EArthquake-prone fault Systems
Quantum Dynamics of the Diffusion of Adsorbates – QDDA
The diffusion of reactive adsorbates on a catalytic substrate is an elementary step in heterogeneous catalysis. Its nature has been by 3He-spin-echo experiments. The project is to study the diffusion process from fundamental principles based on quantum mechanics in order to better understand the experimental outcomes. This study will lead to major progress in the technology of catalytic processes, essential for the world’s economy and sustainable growth.
Ultrafast Reactivity of Biomolecules under Irradiation – RUBI
Ultrafast reactivity of biomolecules under irradiation
Multimodal imaging combining Raman and mass spectrometry applied to tuberculosis – MultiRaMaS
In public health contexts, where results of conventional imaging methodologies are often disappointing, molecular multimodal imaging is within a realm of possibility. Various imaging techniques are informative for functional groups, molecular weights, or special recognition sites, but no individual technique provides optimal answers to all questions. Thus, combining information from two or more measurement platforms is highly attractive.
Innovative analytical methodologies for biotherapeutics analysis in biological samples – MethAmAbs
Because the advent of mAbs is recent, the insights regarding their evolution after administration to the patient are limited. The clinical practice suggests that patients may respond differently to the treatment. To further improve the knowledge and adjust the dosage, it is important to implement a clinical follow-up of patients.To achieve this ambitious goal, an innovative CZE/MSMS method will be developed for the quantification and structural characterization of mAbs in biological samples.
Dual Feedback Streams and Laminar integration of Long-range Inter-areal Processes in Primate Cortex – Dual_Streams
Distinguishing the unknown roles of two feedback pathways that have been identified in the inter-areal projections of primate cerebral cortex. We aim to probe these by studying layer-specific activity in early visual areas during cognitive tasks requiring perceptual integration and attention in human and nonhuman primate. We expect the results to have a major impact on our understanding of the neural mechanisms underlying numerous brain-related phenomena.
Targeting Glutamine Metabolism to prevent Diabetic Cardiovascular Complications – GlutaDiab
Diabetes and related CV disease are associated to exacerbated inflammation, and an activation into a pro-inflammatory status of myeloid cells. Glutamine (Glut) is a critical fuel for the TCA cycle, a key regulatory checkpoint in macrophage polarization. The reported decreased [Glut] in T2D could reflect aberrant glutaminolysis of blood monocytes. The generated metabolites may trigger molecular mechanisms of pro-inflammatory polarization of monocytes in diabetes associated CV complications.
