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Dynamical Nucleus Architecture : a Polymer physics based approach to Chromosome dynamics imaging – DNA-PolyChrom
There is growing experimental evidence in Drosophila that genome architecture and organization have actual functional relevance, both from bulk biochemistry and from live imaging of individual loci. Our theoretical work suggests that evolution drove the folded state of chromosomal domains close to t
Why preschool fails to level the playing field? Examining the role of language interactions in the classroom and assessing an intervention for teachers. – PRESCHOOL
France is one of the countries where socio-economic status (SES) has the greatest influence on academic achievement. This influence of SES is observed very early during development as at the age of 2 low SES children already have lower verbal skills than high SES children. In France, preschool is de
Pestilences and human societies: emergence, evolution and bio-cultural transformations – PSCHEET
The first objective is to identify these epidemics as precisely as possible (archaeological facts, chronology, DNA of pathogen), to retrace their itineraries and understand their dispersal. For the time being, although the chronology and expansion of Justinian plague can be more readily followed tha
Predicting Inner Wood Defects from Outer Bark Features – WoodSeer
Addressing the challenges of the ecological transition related to wood use requires characterizing wood supplies before the first transformation in order to make the best use of them before resorting to more energy-intensive and environmentally costly deconstruction-reconstruction processes. Thus, W
Bridge Functional in Molecular DFT – BRIDGE
The ultimate objective in the present scientific domain is to be able to calculate theoretically, as efficiently as possible, the solvation properties of molecules, macromolecules, interfaces immersed in various solvents. Direct applications can be obviously found in biology, in colloidal physics, i
Impact of STress on uRban trEEs on ciTy air quality – sTREEt
Urban vegetation is a source of ecosystem services, such as reduction of heat island phenomenon via evapotranspiration or support for pollution deposition. Trees emit a number Biogenic Volatile Organic Compounds (BVOC) that can react with atmospheric primary pollutants to form secondary pollutants,
Stone-age memory in a modern world: Further evidence from contamination effects – SAM
The ANR-SAM project aims to study contamination effects in memory in depth at two levels: «ultimate« and «proximal«. First, we will study the various contextual characteristics that can potentially generate this memory effect (ultimate aspects). Next, we will try to identify the mechanisms underlyin
Overcoming the limitations of existing ion channel high-throughput screening and analysis methods by using Bioluminescence Resonance Energy Transfer – CANALBRET
To develop intermolecular BRET assays monitoring the dynamics of protein-protein interactions (PPIs) engaged by ion channels following their activation, using known protein partners and newly discovered ones through an innovative BRET-based PPIs screening assay. 2/ To exemplify the use of BRET intra
Dissecting the molecular mechanism of an antibiotic efflux pump – BIOTIFLUX
Our consortium has three main objectives. The first is to determine the structure of BmrA in multiple states, using cryo-electron microscopy or X-ray crystallography. The second is to investigate the conformational dynamics of BmrA by three different techniques: Hydrogen/Deuterium exchange coupled t
Structural Mass Spectrometry to study the interplay between proteasome complexes regulation mechanisms – ProteasoRegMS
The proteasome is highly diverse in terms of subunit composition, post-translational modifications and binding to different regulators. The ProteasoRegMS project proposes to develop and employ new MS-based approaches to study this diversity in the context of the inflammation of bowel tissues, unders
