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Deep Learning for Constraint Optimization – DELCO
This project aims at building on recent progress in game playing and deep reinforcement learning to design a new generation of more general constraint satisfaction and optimization solvers. Upon completion, this project will contribute to make basic (or even naive) problem formulations far more e
Towards a comprehensive model of plant plasma membrane lipid bilayer – PLAYMOBIL
Elucidation of the molecular basis of plasma membrane organization appears necessary to understand how plants adapt to environmental changes. A crucial point in this respect concerns the asymmetry between the two PM sheets and their coupling, which is currently poorly described. This interdisciplina
In vivo gynogenesis in maize: novel insights into plant double fertilization – NOT-LIKE-DAD
Sexual reproduction is key to the evolutionary success of higher eukaryotes. In all flowering plants, sexual reproduction is characterized by a unique biological process called double fertilization. Double fertilization consists of two separate, parallel fusion events between the two sperm cells and
Individual muscle Coordination strategies and their role in the development of musculoskeletal disorders – COMMODE
Our primary testable hypothesis is that each individual has unique muscle coordination strategies that will have specific mechanical effects on his/her MSK system. As such, some strategies would make people more at risk of developing MSK disorders than others. This hypothesis was presented in an inv
Structure and function of endogenous TFIID-containing complexes – PICen
To better understand the role of native TFIID in endogenous PIC formation and consequent transcription initiation we have the following aims: characterize how TBP is recruited to promoter DNA; characterize the composition and structure of endogenous TFIID-containing PICs; genome-wide identification
Role of the amygdala-prefrontal network in the emergence of anxiety across childhood and adolescence: Impact of early life adversity in a nonhuman primate model – Anxiomonk
Adverse early experiences are among the strongest risk factors for psychiatric disorders, yet the mechanisms by which they shape brain and socio-emotional development remain poorly understood. While rodent studies highlight the role of maternal separation on limbic plasticity, translation to humans
Toward Non-Invasive Ultrasound Surgery – TONUS
There are two main forms of liver tumors: primary hepatic cancer (cancer that starts in the liver, mainly hepatocellular carcinoma) and liver metastases from other tumors, mainly of the gastrointestinal tract (colon or rectum). In 2017, approximately 63,400 new cases of primary liver cancer were rep
Impacts of Microclimatic Processes on foRest bIodiversity redistributioN under macroclimaTe warming – IMPRINT
Species distribution models (SDMs), the toolbox to project biodiversity redistribution under anthropogenic climate change, are based on ambiant-air temperature (i.e. macroclimate) but fail to capture apparent temperature near the ground (i.e. microclimate). Yet, microclimate matters for the distribu
A-site Manganites for mAgNetoelectrics and mulTiferroics from extreme conditionS – AMANTS
The main objectives of the AMANTS project are: O1 – to synthesise new A-site Mn2+A2BB’O6 complex oxides, establish their structures, and explore magnetic and other physical properties. O2 – to synthesise double-double perovskites based upon the newly-discovered MnRMnSbO6 structure type, and explore
Deciphering the Cell Senescence Code to Improve Healthspan – S-ENCODE
There are still many unresolved questions before to envisage anti-senescence therapies as to the clock and cell-type specificity of the senescence program, the interplay between different senescence inducers such as telomere shortening, oxidative stress and oncogenic activation, to what extent senes
