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Deciphering the mechanisms involved in the hyperaccumulation of alkaline earth metals by cyanobacteria – HARLEY
By coupling biochemistry, genetics and microscopy, we intend to identify the molecular actors and mechanisms involved in the formation of intracellular calcium carbonates by some cyanobacteria. This biomineralization process is particularly interesting since it results in a massive intracellular accumulation of earth alkaline elements and offers promising perspectives for remediating pollutions by some radioactives pollutants
Adaptation mechanisms in food-fermenting Penicillium fungi – FUNGADAPT
Adaptation mechanisms in food-fermenting Penicillium fungi
Genetic and epigenetic regulation of life cycle progression in the model brown alga Ectocarpus – Epicycle
The project combined detailed molecular characterisation of life cycle regulatory processes with genome-wide analyses of changes in gene expression and chromatin modifications and provided important insights into the events associated with the alternation of life cycle generations in the brown alga Ectocarpus.
Simulation and Imaging for Mitral Regurgitation – SIMR
Mitral insufficiency is the second most common cause of valve surgery in France. Repair is preferred to replacement when possible. Cardiac ultrasound allows routine assessment of the quality of correction, but it does not allow measurement of the biomechanical impact of interventions on the mitral apparatus. A better understanding of this impact, based on objective physical quantities, would allow optimization of repair techniques.
Self-assembled printable hydrogels from biocompatible amphiphiles for tissue engineering – SELFAMPHI
Recent work shows the properties of self-assembly into fibrils and bilayers of biological surfactants. These molecules form hydrogels. These materials are an interesting alternative to matrices commonly developed from molecules of synthetic origin. The objective is to find bio-based molecules capable of forming hydrogels, whose extrusion properties would be controlled for applications in the biomedical field.
IoniC LIquid Crystals: Towards TunAble-by-Design ElectroLytes – CITADEL
Its overarching goal is to deliver proof of concept demonstration of efficient nanoconfined ionic transport going beyond current state of the art performances of currently used electrolytes to trigger the dawn of safer-by-design next generations key enabling technology (KET) 2.0 solutions in reply to mankind’s energy needs.
Domestication as a step towards reproductive isolation – DomIsol
Genetic exploitation of wild relatives in crop improvement is a key alternative strategy to the massive use of inputs, and promotes the sustainability of agroecosystems. It is however conditioned by cross compatibilities between wild and domesticated forms, and fertility of the resulting progenies. <br />The DOMISOL project aims at characterizing the extent and molecular nature of reproductive barriers between wild and domesticated forms, and at investigating the underlying evolutionary processes.
Role of adipose mitochondrial CB1 signaling in the regulation of energy balance – MitoCB1-Fat
Role of mitochondrial cb1 receptor in the adipose tissue in the physiology of adipocytes and regulation of energy balance in both normal and pthologicla (obesity) conditions
Distributed adaptation and learning over graph signals – DARLING
The objective of the DARLING project is to propose new adaptive, distributed and collaborative learning methods on high-dimensional dynamic graphs in order to extract structured information from the data streams acquired or transiting at the nodes of these graphs. These methods are confronted with two state-of-the-art observation techniques operating at extreme scales: radio astronomy with the SKA instrument and brain imaging by magnetoencephalography.
Reconstructing regional BuRnt Areas from microcharcoal preserved In marine SEdiments – BRAISE
The future evolution of fire activity remains highly uncertain, as fire is a complex process to model. It is necessary to evaluate the performance of fire models outside of current climatic conditions. Records of paleofires from marine sedimentary archives offer this possibility. However, comparisons between models and data remain limited, as there are not yet common units between these two types of data.
