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IntpTN3, a unique RecA-independent homology-directed recombinase: mechanism, structure, partners and applications – IntpTN3
We have published the discovery of a novel integrase encoded by a plasmid (IntpTN3) of the hyperthermophilic anaerobic archaea Thermococcus nautili. In addition to the canonical properties of site-specific integration, excision and inversion, this tyrosine recombinase displays unprecedented activiti
Systematics UNcertainties in Combinations of neutrino Oscillation Results – SUNCORE
The goal of the SUNCORE project is to reduce flux and cross-section systematics in long-baseline neutrino oscillations experiments towards the possible discovery of CP violation in the leptonic sector. This reduction is possible thanks to the use of Near Detector complex in which neutrino beam is m
New selective Inhibitors for deciphering Lipid metabolism and virulence in M. tb – LipInTB
Infection with M.tb leads to the formation of granulomas in the lung, where some of the infected macrophages accumulate lipids in lipid bodies (LB) giving the cells a foamy appearance. In such foamy macrophages (FM), M.tb is able to hydrolyze host lipids into fatty acids that are reused as lipid res
Genome-wide mapping of G4-ligand binding sites at single-base resolution – NEMESES
The aim of this project is to develop and apply techniques that overcome the current limitations for mapping G4s in cells and to identify loci-specific G4 structures at the genome-wide level. This project will allow to develop DNA structure/function elucidation techniques that couple potent small sy
Genetic landscape of cardiomyopathies – Landscardio
Our objectives are: 1) to investigate whether cells bearing heterozygous pathogenic variants in mitochondrial genes will develop mitochondria dysfunction and important transcriptomic changes in the presence of IFN?/TNFa 2) to investigate whether cells bearing heterozygous pathogenic variants will in
Exhaust gas selective sensing using printed RF gas sensors – CARDIF
The main goal of CARDIF project is the development of gas sensors based on new functionalized inks that will interact with specific chemicals species and will be read by transduction at radiofrequency wavelength. The heart of the project is to develop functionalized inks for different chemical speci
Testing the evolutionary species interactions - abiotic stress hypothesis – E-SIASH
Summarized as the “Species Interactions – Abiotic Stress Hypothesis” (SIASH), theory suggests that abiotic forces set range boundaries under stressful conditions, while biotic interaction are most relevant in benign environments. While central to basic and applied research this hypothesis 1) lacks t
Rainfall Wind Turbine or Turbulence – RW-Turb
Few studies showed that the effects of rainfall (rain rate and drop size distribution –DSD-) on wind turbine efficiency are significant, but have surprisingly received little attention. The main goal of WR-Turb is to overcome the current lack of knowledge on this topic through a genuine collaboratio
Light Induced CO2 2-Electron Activation and Mechanistic Insights – LOCO
Performing photocatalytic reactions requires the coupling of multiple photoinduced one-electron transfer steps to multi-electron, multi-proton catalysis. Therefore chemists and physicists need to address urgently the problem of light-induced charge accumulation in photocatalytic systems. Understandi
Integrating microbial METAbolism into CLOUD chemistry: from" omics" to a model – METACLOUD
The main goal of METACLOUD is to improve our fundamental understanding of chemical and biological processes occurring in clouds, with an emphasis on the role of microbial metabolism of C1 compounds in cloud chemistry. To achieve this objective, newly acquired data on the metabolic networks of the cl
