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Remote functionalization of molecules with supramolecular catalysis – REMOTCAT
The activation and functionalization in a selective manner of C-H bonds is an important research direction because C-H bonds are abundant and it is possible to reach molecular complexity in a straightforward manner while reducing the costs and wastes associated to pre-activation. While this results
Structure and molecular function of the pseudopilus in type 2 protein secretion pathway – SYNERGY_T2SS
Many Gram-negative bacteria have in their envelope the type II secretion systems (T2SS) – molecular nanomachines that allows them to shed specific proteins in their culture medium. The proteins that are secreted are often hydrolytic enzymes that break down macromolecules for easier assimilation, or
Optimization framework for desirable and sustainable complex systems – OSCAR
In a context where environmental concerns are pressing, designing environmentally friendly products is now a key requirement, which traditional ecodesign methods cannot address. Life Cycle Assessment (LCA) is used to assess the environmental impacts of products, but current methods only allow partia
Genetic and Mechanical Control of Myoblast Fusion. – MyoFuse
In this project, we wished to investigate the mechanisms whereby TGFß signaling exerts its inhibiting action on fusion and its possible interplay with cellular and environmental mechanical properties. Functional analyses and live observation of cellular behaviors when the function of candidate gene
An antimicrobial origin of organelle targeting peptides – ChloroMitoRAMP
To survive, the proto-endosymbiont had to be able to resist the innate immunity of the host cell, which includes the production of Helical Amphiphilic AntiMicrobial Peptides (HA-RAMPs), a primary defence mechanism of ubiquitous significance. Bacteria facing the action of HA-RAMPs produced by the hos
Control of vesicular flows by golgins – VesicleFiltering
The golgine GMAP-210 recognizes vesicles crossing the Golgi apparatus on the basis of their high curvature and lipid unsaturation level. Do other Golgines recognize other physicochemical properties of membranes? Does the role of GMAP-210 in immunological synapse formation also involve recognition of
Secret Archives of the Basilica of Nicea provided by the Sediments of Iznik Lake – BASILIZNIK-SECRETS
The famous city of Nicaea (now Iznik) was established on the shore of the Lake Iznik (Turkey), 5 km north of the active Middle segment of the North Anatolian Fault (MNAF). In May 325 AD, the city has hosted the first Council of Christians, the founding event of Christian religions. The location of t
An inter- and transdisciplinary project to study collaborations in sustainability science – COLLAB2
We understand collaborations as complex social processes, which need to be understood over time. The main objectives of the project are to 1. characterise inter- and trans-disciplinary collaborations in the field of sustainability sciences: content, stages of projects where collaboration takes pl
Enantioselective Organocatalysis through Hydrogen Bond-Assisted Halogen (X) Bonding – Bond-X-Bond
The goal of the project is to develop new organocatalysts that function by halogen bonding, a stabilizing interaction that is established between halogen atoms attached to an electron withdrawing group and Lewis bases. The halogen bond has been applied to organocatalysis reactions for about ten year
Phosphorus sequestration: contribution of magnetotactic bacteria in oxic–anoxic transition zones – PHOSTORE
Magnetotactic bacteria (MTB), present in natural environments, are able to react to the earth's magnetic field. A magnet is therefore a simple and efficient strategy used for cell concentration from environmental samples. In addition, MTB have the capacity, in certain environmental conditions which
