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Modeling hIerarchy between Cardiac descriptors with MAChine learning – MIC-MAC
The project aims to revisit the representation of diseases from medical imaging, and thus improve the monitoring and risk stratification of both individuals and groups of patients. It proposes first to revisit data integration approaches by taking into account an existing hierarchy in these data, an
Multi-modular Basis of Motor Adaptation and Learning – MultiMod
Our hypothesis is that the adaptation to a novel sensorimotor situation (skill learning or following a peripheral trauma) involves the coordinated recruitment of multiple cerebellar modules. To demonstrate this, we will 1) characterize the role of cerebellar modules in adapting locomotion and in le
Single Nanopore for Analysis of Early Stages of ß-Amyloid Aggregation Leading to Alzheimer’s disease – NANOoligo
Amyloid fibrils are involved in many age-related degenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, as well as type II diabetes 1. The study of such biological higher-order structures requires the identification of numerous self-assembled cytotoxic intermediates fo
Extremal Regression with Applications to Econometrics, Environment and Finance – ExtremReg
This project concentrates around three themes that are central to the area of modern extreme value statistics. First, we contribute to the expanding literature on frontier modeling in three different directions: Task 1: Polynomial spline fitting of the frontier function under shape constraints.
Optical coherence tomography for REtinal Organoid imaging – OREO
Objective : To enable non invasive live imaging of retinal organoids with automated label free cell classification Research hypothesis : We can detect drug action on the same organoid before and after treatment Scientific and technical barriers to be lifted ? Current practice involves sacrificin
ARCHI-SEC: Micro-Architectural Security – ARCHI-SEC
The objectives are as follows: * Highlight the architectural vulnerabilities of processors at model level and anticipate attacks that take advantage of it. We limit our study to Systems based on ARM and RISC-V processors. For software, we use either a custom operating system type «BareMetal« or Lin
SImulations with high-order schemes of tranSport and TurbulencE in a tokaMak – SISTEM
The SISTEM project aims to successfully achieve the strong scaling-up of plasma simulations in view of the fusion operation in a tokamak of unprecedented size, and with stringent plasma conditions. - A 2D high-order non-isothermal ?uid solver including neutral dynamics to simulate turbulent transpor
Fundamental, genetic and clinical aspects of male infertility due to severe sperm flagellar abnormalities – FLAGEL-OME
The first four tasks of our project correspond to different approaches converging towards a single goal: to identify and characterize most actors of flagellogenesis. We will use two different models, the mouse and Trypanosoma brucei, to validate new genes and perform proteomic analyses to identify p
Dislocations and Resistances. Persecutions and Genocidal Violences of Roma, Sinti and Travellers in Western Europe, 1940-1946. – ROMARESIST
The RomaResist project envisages the study, following a comparative and transversal approach, of the various dimensions of the persecution of collectives designated as “Gypsies” (“Zigeuner”, “Zingari”) or “nomads” in Western Europe. In the context of World War II, Roma, Sinti and Travellers were tar
Innovative Chiral Molecules for the Construction of Efficient Circularly Polarized Light Emitting Devices – iChiralight
The main objective of this multidisciplinary project is to design novel chiral TADF molecules (organic, organometallic) and incorporate them as emissive dopant in CP-OLED devices displaying high degrees of both electroluminescence polarization and efficiency. 1) First structure/property study for CP
