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coALescence and biofiLm in thIn GAp phoTObioreactoR – ALLIGATOR
The ALLIGATOR project aims at developping a new type of intensified photobioreactor via an increase of the volume productivity.<br />The proposed configuration consists in a thin-gap bubble column expected to enhance gas-liquid mass transfer and to favor mixing, while allowing high biomass concentration and ensuring light availability on the whole reactor thickness.
Implementing FAIR principles for Theia/OZCAR in situ data information system – FairTOIS
Implementation of FAIR principles in Theia/OZCAR, the national inter-agency information system on land surface research data
Ignition Combustion Explosion Environment and Energetic Materials – ACXEME
Contribution to the understanding of energetic systems, both explosive and propulsive:<br />- Optimization of materials and designed systems,<br />- Prediction of the performances of new compositions under current and future environmental constraints (REACH).
CooperAtive MachinE Learnning and OpTimization – CAMELOT
The goal of the Chaire CaMeLOt is to address the modern challenges of crowd-sourcing, peer-grading and to provide a unified mathematical framework and efficient algorithms to cope with cooperative and decentralized learning and optimization.
To capitalize on activated adventitial fibroblasts metabolism to treat pulmonary hypertension – Gly-Pro-PH
Pulmonary hypertension (PH) is a deadly enigmatic disease of the pulmonary vasculature that is becoming increasingly prevalent worldwide with substantial unmet medical needs. In response to hormonal, inflammatory and environmental stresses such as hypoxia/ischemia, or vascular distention, pulmonary artery adventitial fibroblasts (PAAF) are the first vascular wall cells to exhibit evidence of activation.
Role of Piezo1 in pulmonary arterial hypertension – HTAP
In pulmonary hypertension (PH), both an increase in arterial reactivity and a structural remodeling, causing a thickening of the muscular medial layer of small pulmonary arteries (PAs), are implicated in the etiology of the disease.Several arguments point to an important role for mechanical stress in the stimulation of PA smooth muscle cells (SMCs) proliferation. We hypothesize that opening of the mechanosensitive ion channel Piezo1 in PA SMCs is implicated in experimental and human PAH.
Mechanisms of Cell Wall Mechanosensation for the Regulation of Cell Growth – CellWallSense
This project aims to understand the molecular mechanisms of mechanosesation (force sensing) in the cell wall of fungi, and to understand how it contributes to the growth and mechanical integrity of the cell.
Fundamental, genetic and clinical aspects of male infertility due to severe sperm flagellar abnormalities – FLAGEL-OME
Although multifactorial, male infertility has a strong genetic basis, which has so far not been extensively studied. Previous work permitted to characterize and publish causative mutations in 9 genes. Here, the same consortium will leverage the previously acquired expertise and tools to further investigate the molecular basis of flagellogenesis and to translate this knowledge into actionable information and strategies to improve diagnosis and care of infertile patients.
Redox modulation of rhodium-catalyzed nitrene insertions into C(sp3)-H bonds – CHamRhOx
We plan to design new dirhodium(II) complexes in order to develop a more efficient and subsequently enantioselective intermolecular amination of C(sp3)-H bonds in the context of sustainable chemistry. Our approach will be based on a mechanistic study from the point of view of the design of the catalysts, and the influence of the electronic properties of the ligands on their efficiency, selectivity and stability.
Role of cAMP signalosomes in cardiomyocyte senescence and age-associated heart failure – SIGNALAGE
The increase in longevity is associated with a wider prevalence of heart failure with preserved ejection fraction (HFpEF). While the incidence of HFpEF in terms of mortality is constantly growing, treatments remain unsuccessful because of insufficient knowledge on the mechanisms of cardiac ageing. In an original approach, our consortium proposes to develop and share appropriate models to better understand HF in the context of ageing.
