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spreading of granular pastes: from the particle to end use properties – PASTFLOW
Granular pastes such as gypsum pastes or fresh concrete play an important role in the manufacture of various products in the construction, chemical and food industries. These materials are non-Newtonian fluids whose complex rheological properties need to be understood and described with the help of physical models in order to optimise the end-use properties of these products in conjunction with their formulation.
Exposure to Endocrine Disruptors during early life and child Neurodevelopment: the role of the hypothalamic–pituitary–adrenal axis – EDeN
Child neurodevelopmental disorders usually emerge during childhood, persist into adulthood and are associated with functional impairments. Annual cost of child neurodevelopment disorders has been evaluated at 21€ billion in Europe, making the identification of modifiable risk factors a priority target for public health. In addition to genetic factors known to be important risk factors, exposure to pollutants during critical period for brain development might be involved.
Impact of the aberrant cell-matrix interaction in Non-Alcoholic fatty liver diseases progression – MATRIXNASH
Non-Alcoholic fatty liver diseases (NAFLD) with a 25% worldwide prevalence are leading causes of liver-related morbidity and mortality. Chronic inflammation (NASH) and associated fibrosis are the progressive forms of NAFLD and no pharmacological treatment is yet available. We will investigate how the extracellular matrix and its receptors play a key role in orchestrating chronic inflammation and fibrosis contributing to NAFLD progression.
A central control hub in DNA damage responses: function and regulation of the RBR module – RHiD
Despite their relevance for agriculture upon global change, DNA damage and repair pathways in plants are still poorly understood. Using the plant RBR1 gene as a central hub in DNA damage response (DDR) to identify new players in the plant DDR pathway and investigate their regulation, this work highlights the importance of proteins stability control in DDR, linking players of the cell cycle, the proteasomal degradation machinery and the autophagy to respond to challenges of genome stability.
Secure Software using Whitebox Technology – SWITECH
Secure Software using Whitebox Cryptography
Dense ARray for seismic site effect Estimation – DARE
It is well-known that superficial geological layers can strongly modify the surface ground motion induced by an earthquake, that can lead to significant amplifications. These so-called site effects are highly variable from one site to another. Site-specific studies are therefore necessary to take into account this phenomenon in all its complexity at a given site. However site-specific studies have historically been considered difficult to carry out in low-to-moderate seismicity regions.
Metamorphism and Properties of Snow from 3D Images: Microscale Experimentation and Simulation for a better Understanding of Involved Mechanisms – MiMESis-3D
This project aims at improving the current knowledge and modeling of snow at microscale in order to guide the development of new generation snowpack models, which are necessary for several applications such as climate modeling, avalanche risk forecasting, etc. All the critical ingredients involved in snowpack modeling, namely metamorphism, transfer, mechanical and optical properties of snow, will be revisited and developed further within original multiscale approaches.
Computational analysis of the response of immune repertoires to viruses – RESP-REP
RESP-REP aims to turn the power of high-throughput immune repertoire sequencing into useful medical diagnosis tools, by predicting the immune function and specificity of lymphocyte receptors sequences.
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold
