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CrossOver interference phenomenon: regulating crossover number and spatial PATTerning during meiosis – CO-PATT
CrossOver interference phenomenon: regulating crossover number and spatial PATTerning during meiosis
Shaping 21st Century AI – SHAPING AI ES-T01069X-1
learning revolution” over 10 formative years (2012 to 2021) in three layers: in the media, in the policy space
Mechanisms of intestinal immune response initiation in Peyer's patches – PHAGOMIC
Many emerging pathologies arise from a loss of symbiosis with the microbiota. Dissecting host-microbiota relationship in the gut is therefore critical to define new therapeutic approaches. However, the role of Peyer’s patches (PP), the main immune inductive sites of the gut, in shaping this relationship remains elusive. This project studies the role of the interaction between microbiota and PP phagocytes in intestinal immunity.
HYpoxia and alternatively activated MAcrophaGEs as novel molecular imaging targets for early monitoring of therapy efficacy in Idiopathic Pulmonary Fibrosis – HYMAGE-IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive disease. Therapeutic options are limited with ninedanib and pirfenidone, which slow down the progression of fibrosis. Pulmonary hypoxia is a clinical feature of IPF patients but its exact role in disease progression remains poorly understood. Pulmonary hypoxic areas are found in IPF patients and promote alternative activation of M2 macrophages expressing CD206. The secreted form of heat shock protein (HSP)-90 and its receptor, LRP1, are involved in M2 polarization under hypoxic conditions.
Control of type A Influenza virus Propagation and Immune Responses: Investigating the role of NCOA7-Alternative Start – CAIPIRINAS
Influenza viruses are major pathogenic agents. Current strategies to circumvent influenza infection involve the vaccination against seasonal viruses and few antiviral drugs, with limited efficiency. A better understanding of influenza A virus propagation in infected hosts and its control by the immune system is therefore essential to develop future therapeutic strategies. In this context, CAPIRINAS proposes to study in depth the role and mechanism of action of the antiviral protein NCOA7-AS.
Innovative strategy to treat Charcot-Marie-Tooth patients based on translational readthrough molecules by in vitro screening using CRISPR-Cas9 and iPSc technologies – NeurIT
Innovative strategy to treat patients with Charcot-Marie-Tooth disease based on an in vitro study of readthrough molecules in induced pluripotent stem cell-derived motor neuron models modified by CRISPR-Cas9 molecular scissors technology
Engineering antibacterial cationic amphipathic peptidomimetics for targeting biofilm-embedded and intracellular bacteria – AmphiPep
Bio-inspired design of antibacterial agents able to reach sanctuarized bacteria in in biofilm or inside cells - Impact of the shape of amphiphilic architectures on their modes of interaction with membranes and their mechanisms of action.
Understanding of the bacterial interaction network within seafood microbiome towards a sustainable biopreservation – SEABIOMIC
Understanding the relationship between all bacteria species within the seafood microbiome will help to develop an efficient and reproducible, tailor-made biopreservation strategy, by predicting which protective cultures will be the most appropriate to shift the community toward desirable bacteria.
ET-Nod : Effectors Triggering Nodulation In legumes – ET-Nod
Legumes play a key agronomic and ecological role via symbiosis with nitrogen-fixing rhizobia. We previously identified during the SymEffectors ANR project (2016-2020), an alternative symbiotic pathway, mediated by type III effectors (ET-Nod), that triggers nodulation. This project uncovered the widespread presence of ET-Nod in bradyrhizobia, identified new family members, and advanced the molecular understanding of their mode of action.
EVolution of CO-infecting PAthogens in Rice – EVCOPAR
Co-infection corresponds to the context of infection of the same plant by various pathogen species or genotypes, an increasingly common phenomenon. It is recognized to modify the outcome of each infection. Such effects evidenced at the plant level may further translate into population scale effects, with important epidemiological and evolutionary consequences of multiple infections, but the latter was scarcely investigated.
